Results 91 to 100 of about 822,555 (308)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Rethinking sustainability in engineering education: a call for systemic change
Frontiers in EducationThe integration of engineering education with sustainability is a major requirement in overcoming global environmental, social, and economic challenges.
Omar K. Sabri
doaj +1 more source
, 2018 Inaugural speech spoken in acceptance of the chair ‘Ethics of water engineering’ at the Faculty of Technology, Policy and Management of Delft University of Technology on 16 November ...
Doorn, Neelke
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
ENGINEERING ETHICS AT TECHNICAL UNIVERSITY
Высшее образование в России, 2016 The article covers the issues concerning the formation of engineers' social and cultural competences at higher education institutions. The concept of science and engineering moral neutrality is receding into the past, engineering education standards ...
Alfred A. Dulzon, Ekaterina V. Galanina
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Engineer as an Educator: Goods, Virtues, and Secondary Practices
Studies in Logic, Grammar and RhetoricHow should ethical standards be maintained within engineering and engineering education? The present paper addresses this question with relation to the dominant models of engineering ethics (EE) to show that their limits might be overcome by ...
Machura Piotr
doaj +1 more source
An Introduction to the Integrated Community-Engaged Learning and Ethical Reflection Framework (I-CELER) [PDF]
, 2018 Cultivating ethical Science, Technology, Engineering, and Mathematics researchers and practitioners requires movement beyond reducing ethical instruction to the rational exploration of moral quandaries via case studies and into the complexity of the ...
Coleman, Martin A. +6 more
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, 2007 Prominent ethical and policy issues such as affirmative action and female enrollment in science and engineering revolve around the idea that diversity is good.
B. Williams +24 more
core +1 more source
Engineering ethics and the future [PDF]
, 2016 Responding to the demands of the technology-driven global economy, engineers increase their technical competencies, improve cross-cultural communication skills, and become more innovative, entrepreneurial and flexible (Continental, 2006).
Fell, Elena Vladimirovna +2 more
core +2 more sources