Results 101 to 110 of about 3,419,758 (350)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

TOWARD SOFTWARE ENGINEERING PRINCIPLES BASED ON ISLAMIC ETHICAL VALUES

International Islamic University Malaysia Engineering Journal, 2010
Software is the core for Computer-based applications which became an essential part for critical control systems, health and human life guard systems, financial and banking systems, educational and other systems.
shihab A. Hameed
doaj   +1 more source

Teaching Ethics and Sustainability to Informatics Engineering Students, An Almost 30 Years’ Experience [PDF]

, 2020
Maria Jose Casan, Marc Alier, Ariadna Lloréns García   +2 more
openalex   +1 more source

Engineering standards for trauma and orthopaedic implants worldwide : a systematic review protocol [PDF]

, 2018
Introduction Despite multiple scandals in the medical implant sector, premarket testing has been the attention of little published research. Complications related to new devices, such as the DePuy Articular Surface Replacement (ASR, DePuy Synthes ...
Atinga, John, Henshaw, Frederick, Karasouli, Eleni, King, Richard, Langton, David, Madete, June, Metcalfe, Andrew J., Mutiso, Vincent, Otsyeno, Fred, Rahman, Usama, Underwood, Martin, Williams, M. A.   +11 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

ENGINEERING ETHICS AT TECHNICAL UNIVERSITY

Высшее образование в России, 2016
The article covers the issues concerning the formation of engineers' social and cultural competences at higher education institutions. The concept of science and engineering moral neutrality is receding into the past, engineering education standards ...
Alfred A. Dulzon, Ekaterina V. Galanina
doaj  

Ethics of Blockchain by Design: Guiding a Responsible Future for Healthcare Innovation

Blockchain in Healthcare Today
The rapid evolution of blockchain technology within healthcare presents unparalleled opportunities for advancements, including enhanced patient data security, decentralized systems for trustless operations, and transparent supply chain management ...
Muthu Ramachandran
doaj   +1 more source

Is diversity good?

, 2007
Prominent ethical and policy issues such as affirmative action and female enrollment in science and engineering revolve around the idea that diversity is good.
B. Williams, D. E. Chubin, D. Tilman, E. Baum, E. Gates, G. E. Moore, G. Orfield, G. Sher, H. Coates, J. F. Sullivan, J. J. Cohen, J. Lefevre, K. A. Appiah, L. R. Wise, M. Bouville, M. L. Weitzman, M. R. Killenbeck, Mathieu Bouville, N. Lane, N. M. Pless, P. Gurin, R. M. Felder, S. Maitzen, T. P. O’Brien, W. A. Wulf   +24 more
core   +1 more source

Engineering ethics and the future [PDF]

, 2016
Responding to the demands of the technology-driven global economy, engineers increase their technical competencies, improve cross-cultural communication skills, and become more innovative, entrepreneurial and flexible (Continental, 2006).
Fell, Elena Vladimirovna, Lukianov, Aleksandr, Lukianova, Natalia Aleksandrovna   +2 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source