Results 101 to 110 of about 2,890,467 (353)
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh+5 more
wiley +1 more source
Ethics of the Engineering Profession [PDF]
Society of Mechanical Engineers on this Joint Committee are expecting to present again the proposed code, revised in cobperation with the representatives of the other societies, at the forthcoming Spring Meeting of the Society. The Committee still adheres to its plan of a Committee on Professional Conduct to enforce the code, and in fact regards this ...
openaire +2 more sources
Unpacking the role of AI ethics online education for science and engineering students
As artificial intelligence (AI) technology rapidly advances, it becomes imperative to equip students with tools to navigate through the many intricate ethical considerations surrounding its development and use.
M. Usher, M. Barak
semanticscholar +1 more source
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha+10 more
wiley +1 more source
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban+12 more
wiley +1 more source
Ethics is increasingly considered as a new dimension of professionalism and as a competence professionnals need do develop in order to revisit the foundations, goals and means of their action, driving them to engage in a professional practice that is ...
Aiguier Grégory, Didier Christelle
doaj +1 more source
The Ethics of the Mechanical Engineer [PDF]
n ...
openaire +2 more sources
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan+9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts+8 more
wiley +1 more source
Responsible use of Generative AI in chemical engineering
Generative Artificial Intelligence is a rapidly developing area being used to create powerful tools which have the potential to change a wide range of professional practices in chemical engineering.
Thorin Daniel, Jin Xuan
doaj +1 more source