Results 61 to 70 of about 3,419,758 (350)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
A Guided Tour Of Conceptual Engineering and Conceptual Ethics [PDF]
, 2019 In this Introduction, we aim to introduce the reader to the basic topic of this book. As part of this, we explain why we are using two different expressions (‘conceptual engineering’ and ‘conceptual ethics’) to describe the topics in the book.
Cappelen, Herman, Plunkett, David
core
FEBS Letters, EarlyView.This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk +3 more
wiley +1 more source
Forming engineers' sociocultural competence: Engineering ethics at Tomsk polytechnic university [PDF]
, 2015 The aim of the present research is to discuss Tomsk Polytechnic University in respect of forming engineers' sociocultural competence and teaching engineering ethics. Today international standards of training engineers cover efficient communication skills,
Dulson, Alfred Andreewitsch +2 more
core +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
آموزش مهندسی ایران, 2020 The purpose of this research is to investigate the emphasis on the educational ethics at the engineering universities of Iran and comparing with top engineering universities of the world.
Hossein Abdullahi +1 more
doaj +1 more source
ETHICS-2023 Session C4 - Workshop: STS Postures as a framework for teaching ethics throughout the engineering curriculum [PDF]
, 2023 Nicole Mogul, Tim Reedy
openalex +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The risks of hydraulic fracturing and the responsibilities of engineers
Elementa: Science of the Anthropocene, 2017 One third of U.S. natural gas is extracted by injecting fluid at high pressure into shale formations, a process associated with a number of possible hazards and risks that have become the subject of intense public controversy.
Robert Kirkman +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source