Results 61 to 70 of about 822,555 (308)

Identifying and Ranking the Components of Engineering Ethics with a Multi-Criteria Decision-Making Approach

آموزش مهندسی ایران, 2020
Engineering ethics deals with moral issues and decisions confronting individuals and organizations engaged in engineering, and it is, therefore, the ability and the responsibility of all engineers to evaluate their decisions based on the general well ...
mahdi safaei , Ardalan Feili , omid jabari , seyed ahmad Jenabali Jahromi   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Forming engineers' sociocultural competence: Engineering ethics at Tomsk polytechnic university [PDF]

, 2015
The aim of the present research is to discuss Tomsk Polytechnic University in respect of forming engineers' sociocultural competence and teaching engineering ethics. Today international standards of training engineers cover efficient communication skills,
Dulson, Alfred Andreewitsch, Galanina, Ekaterina Vladimirovna, Schwab, A.   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Code of professional ethics of engineering in Iran

آموزش مهندسی ایران, 2015
Professional ethics set of regulations and rules which define ethical practice for that profession specifically. Engineering ethics in general is the application of code of ethics and professional standards.
Mehran Rahmani, Javad Majrouhi
doaj   +1 more source

Ethical and Social Aspects of Self-Driving Cars

, 2018
As an envisaged future of transportation, self-driving cars are being discussed from various perspectives, including social, economical, engineering, computer science, design, and ethics.
Dodig-Crnkovic, Gordana, Holstein, Tobias, Pelliccione, Patrizio   +2 more
core   +1 more source

Teaching engineering ethics with sustainability as context [PDF]

, 2012
Purpose – The purpose of this paper is to ascertain the engagement and response of students to the teaching of engineering ethics incorporating a macro ethical framework whereby sustainability is viewed as context to professional practice.
Byrne, Edmond P.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

We Could, but Should We? Ethical Considerations for Providing Access to GeoCities and Other Historical Digital Collections [PDF]

, 2020
We live in an era in which the ways that we can make sense of our past are evolving as more artifacts from that past become digital. At the same time, the responsibilities of traditional gatekeepers who have negotiated the ethics of historical data ...
Bastian M., Cohen D., Dent P., Frankel C., Hallinan B., Jenkins H., Klein E., Lin J., McTavish S., Milligan I., Milligan I., Smith M.   +11 more
core   +1 more source