Results 81 to 90 of about 822,555 (308)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Software engineering ethics [PDF]

Software engineering ethics is reviewed. The following subject areas are covered: lack of a system viewpoint; arrogance of PC DOS software vendors; violation od upward compatibility; internet worm; internet worm revisited; student cheating and company ...
Bown, Rodney L.
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Ethics of Blockchain by Design: Guiding a Responsible Future for Healthcare Innovation

Blockchain in Healthcare Today
The rapid evolution of blockchain technology within healthcare presents unparalleled opportunities for advancements, including enhanced patient data security, decentralized systems for trustless operations, and transparent supply chain management ...
Muthu Ramachandran
doaj   +1 more source

Ethics in engineering: Student perceptions and their professional identity development

Journal of Technology and Science Education, 2013
Professional ethics instruction in engineering is commonly conducted by examining case studies in light of the code of conduct of a suitable professional body.
Brad Stappenbelt
doaj   +1 more source

Introducing Preservice STEM Teachers to Computer Science: A Narrative of Theoretically Oriented Design [PDF]

, 2018
This paper narrates the process of designing a curricular unit that serves to introduce preservice science, technology, engineering, and mathematics (STEM) teachers to computer science (CS) education.
Harron, Jason
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

TOWARD SOFTWARE ENGINEERING PRINCIPLES BASED ON ISLAMIC ETHICAL VALUES

International Islamic University Malaysia Engineering Journal, 2010
Software is the core for Computer-based applications which became an essential part for critical control systems, health and human life guard systems, financial and banking systems, educational and other systems.
shihab A. Hameed
doaj   +1 more source

Engineering standards for trauma and orthopaedic implants worldwide : a systematic review protocol [PDF]

, 2018
Introduction Despite multiple scandals in the medical implant sector, premarket testing has been the attention of little published research. Complications related to new devices, such as the DePuy Articular Surface Replacement (ASR, DePuy Synthes ...
Atinga, John, Henshaw, Frederick, Karasouli, Eleni, King, Richard, Langton, David, Madete, June, Metcalfe, Andrew J., Mutiso, Vincent, Otsyeno, Fred, Rahman, Usama, Underwood, Martin, Williams, M. A.   +11 more
core   +3 more sources