Results 91 to 100 of about 1,321,882 (316)

The John Fritz medal for general Goethals: Awarded by engineering societies [PDF]

, 1919

openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EDUCATIONAL TECHNOLOGIES IN TRAINING OF CHEMICAL PROCESS ENGINEERS

Высшее образование в России, 2016
Technification of educational process is a stable development trend for institutions of higher education. Exemplified by the course “General chemical engineering”, implementation of modular and context educational technology is shown.
Farida T. Shageeva, Vasily G. Ivanov
doaj  

Improving the thermal properties of lightweight concrete exterior walls [PDF]

E3S Web of Conferences
This article is devoted to the development of energy-efficient porous expanded clay concrete for exterior walls. Experimental data confirming the expediency of designing the optimal composition of porous concrete according to the general method of ...
Goncharova Natalia, Ababakirova Zebuniso, Davlyatov Shokhrukh, Umarov Shodiljon, Mirzababayeva Sahiba   +4 more
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges

Frontiers in Microbiology, 2018
Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M. Chánique, Loreto P. Parra, Loreto P. Parra   +2 more
doaj   +1 more source

A generic platform for the immobilisation of engineered biocatalysts

Tetrahedron, 2019
Abstract The application of biocatalysis in the pharmaceutical industry is rapidly growing as a result of increased access to enzymes that meet the demands of industrial processes. This expansion of activity has led to a corresponding increase in the demand for immobilised enzymes.
Thompson, Matthew P., Derrington, Sasha R., Heath, Rachel S., Porter, Joanne L., Mangas-Sanchez, Juan, Devine, Paul N., Truppo, Matthew D., Turner, Nicholas J.   +7 more
openaire   +3 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Local microenvironment reactive zone engineering promotes water activation

Materials Reports: Energy
Beyond conventional electrocatalyst engineering, recent studies have demonstrated the effectiveness of manipulating the local reaction environment to enhance the performance of electrocatalytic reactions.
Jian Luo, Junjie Zheng, Mingjie Wu, Fang Dong, Yuyu Liu, Jinli Qiao, Yingkui Yang   +6 more
doaj   +1 more source

Preliminary report on the general geology and engineering geology of Noonan quadrangle, North Dakota [PDF]

, 1947
Roland C. Townsend
openalex   +1 more source