Results 91 to 100 of about 10,429,289 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Engineering Pedagogy in Vocational Education: Methodological Aspect

Высшее образование в России, 2018
The paper examines the questions concerning the methodological status of engineering pedagogy in the system of vocational education, specifies its subject area.
P. F. Kubrushko, D. O. Eprikyan
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

EDUCATIONAL TECHNOLOGIES IN TRAINING OF CHEMICAL PROCESS ENGINEERS

Высшее образование в России, 2016
Technification of educational process is a stable development trend for institutions of higher education. Exemplified by the course “General chemical engineering”, implementation of modular and context educational technology is shown.
Farida T. Shageeva, Vasily G. Ivanov
doaj  

Comments on the problems solving methodology in education of civil engineering in Brazil

Revista Brasileira de Ensino de Ciência e Tecnologia, 2019
Academic works have indicated which didactic methods to teaching engineers fail in the professional preparation, despite the international effort to create competences for engineering students.
Paloma Aparecida Alves, Tales Alexandre Aversi-Ferreira   +1 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Improving the thermal properties of lightweight concrete exterior walls [PDF]

E3S Web of Conferences
This article is devoted to the development of energy-efficient porous expanded clay concrete for exterior walls. Experimental data confirming the expediency of designing the optimal composition of porous concrete according to the general method of ...
Goncharova Natalia, Ababakirova Zebuniso, Davlyatov Shokhrukh, Umarov Shodiljon, Mirzababayeva Sahiba   +4 more
doaj   +1 more source

Describing 'generic' graduate engineer skills

, 2018
Project-Based Learning, Qualitative Research, Grounded Theory, Creativity Being able to describe skills effectively is essential for teaching and enabling students to learn skills. A previous study [1], investigating the development of real industrial problem solving skills in a taught Masters course, found inadequate skill descriptions were a ...
Shawcross, JK, Ridgman, Tom W
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source