Results 91 to 100 of about 9,706,975 (343)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Engineering Pedagogy in Vocational Education: Methodological Aspect
Высшее образование в России, 2018 The paper examines the questions concerning the methodological status of engineering pedagogy in the system of vocational education, specifies its subject area.
P. F. Kubrushko, D. O. Eprikyan
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Technology and Science Education, 2016 Building a solid foundation of conceptual knowledge is critical for students in electrical engineering. This case study explores the use of simulation videos to illustrate complicated conceptual knowledge in foundational communications and signal ...
Baiyun Chen, Lei Wei, Huihui Li
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
EDUCATIONAL TECHNOLOGIES IN TRAINING OF CHEMICAL PROCESS ENGINEERS
Высшее образование в России, 2016 Technification of educational process is a stable development trend for institutions of higher education. Exemplified by the course “General chemical engineering”, implementation of modular and context educational technology is shown.
Farida T. Shageeva, Vasily G. Ivanov
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IL-34 and Immune Checkpoint Inhibitors Resistant through Macrophages: Pan-Cancer Overview
Journal of Inflammation Research, 2023 Mohammed Safi,1,* Al-shaebi Fadhl,1,* Yousif A Algabri,2 Caiqing Zhang1 1Department of Respiratory Diseases, Shandong Second Provincial General Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Biomedical ...
Safi M, Fadhl AS, Algabri YA, Zhang C
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