Results 81 to 90 of about 174,821 (298)

Framing professional competencies for systems thinking in practice: final report of an action research eSTEeM inquiry [PDF]

open access: yes, 2018
The Open University eSTEeM project (The OU Centre for STEM Pedagogy) was a 12-month inquiry beginning March 2017 building on an initial eSTEeM project (2014-2016) entitled ‘Enhancing Systems Thinking in Practice in the Workplace’ reported on in Reynolds ...
Reynolds, Martin   +2 more
core  

Considering the Smartphone Learner: developing innovation to investigate the opportunities for students and their interest [PDF]

open access: yes, 2012
Ownership of mobile smartphones amongst the general consumer, professionals and students is growing exponentially. The potential for smartphones in education builds upon experience described in the extensive literature on mobile learning from the ...
Middleton, Andrew   +2 more
core   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

open access: yesAdvanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li   +12 more
wiley   +1 more source

THE NEW FORMAT OF SOLVING THE TASKS OF THE INTERNATIONAL INTEGRATION OF ENGINEERING EDUCATION

open access: yesВысшее образование в России, 2022
The article presents the experience of research and education center founded on the base ofState Technical University – MADI to improve the educational process in technical higher school taking into account the best international and domestic engineering
Vyacheslav M. Prikhodko   +2 more
doaj  

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

open access: yesAdvanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang   +16 more
wiley   +1 more source

Development and Transfer of Innovative Problem Solving Strategies and Related Confidence in Biomedical Engineering [PDF]

open access: yes, 2019
Twenty-nine biomedical engineering (BME) undergraduates participated in a challenge-based instruction biotransport course, offered by the UT Austin BME Department in an accelerated format, at the University of Cambridge.
Clegg, John R., Diller, Kenneth R.
core   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

open access: yesAdvanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang   +8 more
wiley   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

open access: yesAdvanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li   +12 more
wiley   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

open access: yesAdvanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang   +12 more
wiley   +1 more source

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