Results 101 to 110 of about 901,591 (284)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Development theories and development experience: half a century journey [PDF]

This paper examines the impact that development theories have had on development policies, and the inverse impact of actual successes and failures in the global South on development thinking.
Popov, Vladimir
core   +1 more source

Teaching in Context: Integrating Mathematical Thinking and Personal Development Planning into the Curriculum for Part-Time, Distance-Learning Engineering Students [PDF]

, 2018
This paper describes changes to the way mathematics is taught to engineering students at The Open University, moving away from service teaching via generic mathematics modules to incorporating mathematics teaching into the core engineering curriculum ...
Goodyear, Alec, Morris, Carol, Organ, Sally   +2 more
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Narrative in design development

, 2013
This paper describes the value of narrative used with ideation tools in aiding the rapid production of product concepts and designs for masters students of graphics, fine art, product and industrial design.
Childs, P, Grigg, J, ZHAO, Y
core  

Systems practice in engineering: reflections on doctoral level systems supervision [PDF]

, 2011
The Industrial Doctorate Centre (IDC) in Systems, a collaboration between the University of Bristol and the University of Bath, offers an Engineering Doctorate (EngD) in Systems Programme which is aimed at high-calibre engineers from graduate level to ...
Yearworth, M
core  

On site challenges for the construction of 16-storey condominium: as observed by a young civil engineering technologist [PDF]

, 2020
The difference between an engineer and an engineering technologist is that, an engineer would mainly focus and produce structural designs based on engineering calculations, while the job of an engineering technologist is to execute the design in the real
Chan, C. M., Ganageswaran, S., Srinivasan, M.   +2 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Integrating engineering into medical education: A scoping review

Current Medicine Research and Practice
Background: As healthcare systems grow increasingly complex and technology-driven, there is a pressing need to equip future physicians with problem-solving skills, systems thinking and design principles that define engineering disciplines.
Stephanie Quon, Sarah Thompson, Daniel Nguyen, Emily Carter, Michael Lee   +4 more
doaj   +1 more source