Results 121 to 130 of about 25,949 (261)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Developing innovation through knowledge of thinking preferences [PDF]

, 2005
Many business enterprises are facing difficulties and being required to be innovative in their policies and practices as they face competition within a global economy.
Al-Humaidi, Omar S.I., Al-Humaidi, Omar S I   +1 more
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Integrating engineering into medical education: A scoping review

Current Medicine Research and Practice
Background: As healthcare systems grow increasingly complex and technology-driven, there is a pressing need to equip future physicians with problem-solving skills, systems thinking and design principles that define engineering disciplines.
Stephanie Quon, Sarah Thompson, Daniel Nguyen, Emily Carter, Michael Lee   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Case Studies in Applying Design Thinking to Course Design in Computer Engineering

, 2023
This Innovative Practice Full Paper describes case studies from an instructional design process based on design thinking, illustrating tools used during stages of design.
Mina, Mani, Rover, Diane, Jones, Phillip, Fila, Nicholas D., Duwe, Henry   +4 more
core  

Thinking outside the box means thinking outside the search engine

Memory & Cognition
Abstract This study investigates the impact of internet access on creativity and identifies potential hidden costs of internet use for groups. Using the alternative uses task, we randomized participants ( N  = 244) into separate conditions to generate ideas for nonstandard ...
Oppenheimer, Daniel M., Patterson, Mark T.   +1 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A curriculum framework for flexible engineering degrees in South Africa

, 2014
South Africa produces too few engineers to meet its development needs. The number of graduating engineers is slowly increasing, but is still only about 2000 per year, serving a population of over 50 million. Data from the Council on Higher Education (CHE
Shay, Suellen, Pearce, Howard, Grayson, Diane, Collier-Reed, Brandon I   +3 more
core