Results 131 to 140 of about 25,949 (261)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Framework for Enhancing Outside-the-box Thinking in Engineering Design, Demonstrated on a Case Study

, 2012
This paper introduces a framework for enhancing creative thinking in engineering design. As a flexible methodology, the proposed Creative Engineering Design (CED) framework integrates a new concept development tool, the Concept Assessment Taxonomy (CAT),
W. John Dartnall, Roser, HM, Dartnall, WJ, Roser, H. M., Dartnall, W. J., Holger M. Roser   +5 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Developing systems thinking for sustainable development in engineering education

, 2015
Present and future generations of engineering students are facing very different challenges than what engineering students did some 20-30 years back. The ability to appreciate the whole and assess complexity are abilities that become more and more urgent,
Svanström, M., Claesson, A. Nyström
core  

Integrating green management case studies in construction engineering courses to improve students' critical thinking

With the growing need in the industry for sustainable practices and critical thinking abilities, the inclusion of green management case studies in construction engineering education is becoming more and more crucial.
Mingyi, Ying, Yingqiao, Xia, Supeni, Eris Elianddy, Tang, Sai Hong   +3 more
core   +1 more source

Ingenuity in Action: Connecting Tinkering to Engineering Design Processes

, 2013
The Lawrence Hall of Science, a science center, seeks to replicate real-world engineering at the Ingenuity in Action exhibit, which consists of three open-ended challenges.
Wang, Jennifer, Jennifer Wang, Gretchen Walker, Werner-Avidon, Maia, Smith, Brooke, Lisa Newton, Brooke Smith, Walker, Gretchen, Scott Randol, Maia Werner-Avidon, Randol, Scott, Newton, Lisa   +11 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Thinking Technology in order to think engineering education

, 2008
The aim of this paper is to define the various meanings of the word “technology” and the history of this concept. It will point out our definition of the word “technology” which implies others relationships between science and technology. Finally, it will show the implications of such a definition upon engineering education.
Faucheux, Michel, Forest, Joëlle
openaire   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source