Results 111 to 120 of about 25,949 (261)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Design Thinking Integrated into Model-Based Systems Engineering of Operational Architectures

, 2023
This research project investigates how to integrate newer, innovative approaches of problem solving and design including design thinking and agile methods in the mission engineering of defense systems. We adopt the design thinking perspectives within the
Giachetti, Ronald
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Development of an interdisciplinary participatory design course with futures thinking for engineering students.

, 2016
In the future, engineers are expected to have innovative thinking and abilities of interdisciplinary and integration. Therefore, we combined three courses from Department of Civil Engineering, Graduate Institute of Building and Planning and Department of
Chen, M. D.;Lai, S. Y.;Song, M. M.;Hsieh, S. H.
core  

The formation of students' engineering thinking as a way to create new techniques, technologies, materials

, 2020
Engineering thinking is regarded as the quality of the person, which is stimulating the human need for the creation of new techniques, technologies and materials.
Gilmanshina S., Gilmanshina Suriya Irekovna, Gilmanshin I., Gilmanshin Iskander Rafailevich   +3 more
core  

Design Thinking (DT) in Engineering Education (EE): A Systematic Literature Review (SLR) [PDF]

Trabajo presentado en el “13th International Conference on Industrial Engineering and Industrial Management/XXIII Congreso en Ingeniería de Organización (CIO 2019)”, Gijon (Asturias, Spain) , 11 y 12 de julio de 2019[EN] Design Thinking not only is a ...
Acebo Moral, Enrique, Herrera, Liliana, Miguel Dávila, José Ángel   +2 more
core   +1 more source

ROBOTICS IN PRIMARY SCHOOL: FROM PLAYFUL ACTIVITY TO CONSCIOUS STEM PROJECTING

Неперервна професійна освіта: теорія та практика
The article explores the role of educational robotics as a universal didactic tool within the context of Industry 4.0. The purpose of the study is to substantiate the mechanisms of a systematic transition from playful activity to conscious STEM ...
Marianna Shvardak , Oksana Popovych
doaj   +1 more source

Examining the impact of higher-order thinking and GAI chatbots on engineering creativity in higher education

Scientific Reports
The development of higher-order thinking and creativity is widely regarded as a central objective in engineering education. With the increasing use of generative artificial intelligence (GAI) tools, particularly AI chatbots, there is growing interest in ...
Yi Deng, Huifen Guo, Yi Dai
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source