Results 101 to 110 of about 25,949 (261)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Applying Systems Engineering to Optimise the Operation and Maintenance of Railway Vehicles throughout the Value Chain

, 2009
A recent move by the UK government to purchase two new railway vehicle fleets from the provider offering the lowest whole-life, whole-system cost creates significant challenges to traditional manufacturers and their extended enterprises.
Clayton, Richard J., Michael J. Provost (7207259), Richard J. Clayton (7204499), Lovell, Jeremy, Samir Dani (5826068), Chris Backhouse (1249161), Backhouse, C.J., Provost, Michael J., Dani, Samir, J. Lovell (7207262)   +9 more
core  

Systems Thinking Education—Seeing the Forest through the Trees

Systems, 2018
Systems thinking is an indispensable tool in comprehending and analyzing real-world phenomena. Observed processes are naturally composed of many interconnected components which ought to be studied jointly rather than individually.
Sigal Koral Kordova, Moti Frank, Anat Nissel Miller   +2 more
doaj   +1 more source

Engineering Strategic Thinking

, 2018
Strategy is generally identified as important. Unfortunately the field of strategy provides a number of challenges. For instance, there does not appear to be consensus within the literature on what strategic thinking is nor how to measure it. Additionally there does not appear to be any frameworks that allow strategic thinking to be engineered. For the
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exploring the roles of paradoxical tensions, paradoxical thinking, and team psychological capital on the creativity of engineering university students

BMC Psychology
Background The multifaceted challenges encountered by engineering university students generate paradoxical tensions, which serve as catalysts for fostering creativity.
Huifen Guo, Zhen Zhou, Fengqi Ma
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The formation of students' engineering thinking as a way to create new techniques, technologies, materials [PDF]

, 2016
Engineering thinking is regarded as the quality of the person, which is stimulating the human need for the creation of new techniques, technologies and materials.
Gilmanshina S., Gilmanshina Suriya Irekovna, Gilmanshin I., Gilmanshin Iskander Rafailevich   +3 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Systems Thinking Principles for Making Change

Systems
Traditionally, systems thinking support has relied on an ever-increasing plethora of systems tools, methods, and approaches. Arguably though, such support requires something different from, and more accessible than, detailed instruction on somewhat ...
Martin Reynolds
doaj   +1 more source