Results 61 to 70 of about 903,268 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Developing an undergraduate software engineering degree [PDF]

, 2003
As those who have done it can attest, developing an undergraduate degree in software engineering is a daunting and challenging task, and there have been instances where a department has tried, but failed to get its program approved.
Armarego, J., Bagert, D.J., Eisenbach, S., Hilburn, T.B., Naveda, J.F., Seidman, S.   +5 more
core   +1 more source

Unpacking capabilities underlying design (thinking) process [PDF]

, 2020
Engineering graduates must know how to frame and solve non-routine problems. While design classes explicitly teach problem framing and solving, it is lacking throughout much of the rest of the engineering curriculum and is often relegated to capstone ...
Beckman, S, Dzombak, R
core  

Whole life thinking and engineering the future [PDF]

, 2014
Whole-life thinking for engineers working on the built environment has become more important in a fast changing world.Engineers are increasingly concerned with complex systems, in which the parts interact with each other and with the outside world in ...
Flanagan, Roger
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessing the validity and reliability of creative thinking skills module in a pilot study on engineering undergraduate in Malaysia

Asian Journal of Assessment in Teaching and Learning, 2020
This research paper presents the outcome of a research conducted to assess and determine the Validity and Reliability coefficient of Creative Thinking Skills for Conceptual Engineering Design Module administered to engineering undergraduates at a private
Yaw Long Chua, Balamuralithara Balakrishnan, Voon Chiet Chai, Yit Yan Koh   +3 more
doaj   +1 more source

Bringing the Outside World In: Using Mixed Panel Assessment of Oral Presentations with Electrical and Electronic Engineering Students [PDF]

, 2016
Engineering students have been portrayed as having poor oral communication skills despite oral communication competence being a key factor in future career success.
Bolster, Averil, Le Kernec, Julien, Levrai, Peter   +2 more
core   +1 more source

Engineering Strategic Thinking

, 2018
Strategy is generally identified as important. Unfortunately the field of strategy provides a number of challenges. For instance, there does not appear to be consensus within the literature on what strategic thinking is nor how to measure it. Additionally there does not appear to be any frameworks that allow strategic thinking to be engineered. For the
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

How does the development of STEM products in the learning process affect the development of students’ applied-oriented skills?

Frontiers in Education
In the modern education system, developing learners’ ability to apply theoretical knowledge in practice has become one of the key priorities. In this regard, STEM technologies provide opportunities to teach physics in a practice-oriented format, serving ...
Sherzod Ramankulov, Ali Çoruh, Makpal Nurizinova, Gulnara Rizakhojayeva, Kazhymukan Kelesbayev, Shakhrizada Khikmatulla   +5 more
doaj   +1 more source