Results 61 to 70 of about 51,670 (258)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

How does the development of STEM products in the learning process affect the development of students’ applied-oriented skills?

Frontiers in Education
In the modern education system, developing learners’ ability to apply theoretical knowledge in practice has become one of the key priorities. In this regard, STEM technologies provide opportunities to teach physics in a practice-oriented format, serving ...
Sherzod Ramankulov, Ali Çoruh, Makpal Nurizinova, Gulnara Rizakhojayeva, Kazhymukan Kelesbayev, Shakhrizada Khikmatulla   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Assessing the validity and reliability of creative thinking skills module in a pilot study on engineering undergraduate in Malaysia

Asian Journal of Assessment in Teaching and Learning, 2020
This research paper presents the outcome of a research conducted to assess and determine the Validity and Reliability coefficient of Creative Thinking Skills for Conceptual Engineering Design Module administered to engineering undergraduates at a private
Yaw Long Chua, Balamuralithara Balakrishnan, Voon Chiet Chai, Yit Yan Koh   +3 more
doaj   +1 more source

Whole-life Thinking and Engineering the Future [PDF]

Frontiers of Engineering Management, 2014
Whole-life thinking for engineers working on the built environment has become more important in a fast changing world.Engineers are increasingly concerned with complex systems, in which the parts interact with each other and with the outside world in many ways – the relationships between the parts determine how the system behaves.
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Creative thinking development in engineering students

آموزش مهندسی ایران, 2014
What is creativity? Who is considered a creative person? Can creativity be learned? What is the role of creativity in engineering profession? These are some questions that often come to mind.
Hossein Memarian
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

OUTCOMES OF CRITICAL THINKING IN ENGINEERING EDUCATION: A SYSTEMATIC REVIEW

آموزش مهندسی ایران
Identifying, cultivating, and developing critical thinking competencies is one of the most important success factors of engineers in problem-finding, problem-oriented, problematizing and recognizing innovative solutions and solving complex problems.
Zahra Akbaripordanjani , Keyvan Salehi
doaj   +1 more source