Results 71 to 80 of about 901,591 (284)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Set-Based Concurrent Engineering process within the LeanPPD environment [PDF]
, 2011 This paper presents a newly defined set-based concurrent engineering process, which the authors believe addresses some of the key challenges faced by engineering enterprises in the 21st century. The main principles of Set-Based Concurrent Engineering (
Al-Ashaab, Ahmed +5 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
OUTCOMES OF CRITICAL THINKING IN ENGINEERING EDUCATION: A SYSTEMATIC REVIEW
آموزش مهندسی ایرانIdentifying, cultivating, and developing critical thinking competencies is one of the most important success factors of engineers in problem-finding, problem-oriented, problematizing and recognizing innovative solutions and solving complex problems.
Zahra Akbaripordanjani , Keyvan Salehi
doaj +1 more source
Applying Systems Thinking to Engineering and Design
Systems, 2018 The application of Systems Thinking principles to Systems Engineering is synergistic, resulting in superior systems, products, and designs. However, there is little practical information available in the literature that describes how this can be done. In
Jamie P. Monat, Thomas F. Gannon
doaj +1 more source
Framing professional competencies for systems thinking in practice: final report of an action research eSTEeM inquiry [PDF]
, 2018 The Open University eSTEeM project (The OU Centre for STEM Pedagogy) was a 12-month inquiry beginning March 2017 building on an initial eSTEeM project (2014-2016) entitled ‘Enhancing Systems Thinking in Practice in the Workplace’ reported on in Reynolds ...
Reynolds, Martin +2 more
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
CONTINUING EDUCATION MODEL OF SCHOOL OF FUTURE (CASE STUDY OF ENGINEERING SCHOOL)
Открытое образование (Москва), 2016 The paper presents the concept of continuous engineering education for the educational complex kindergarten-school-high school. Basing on the space-time model of memory and thinking, we define the didactic requirements for organization of the educational
Olga A. Karlova, Nikolay I. Pak
doaj +1 more source
Safe Environments for Innovation: the development of a new multidisciplinary masters programme [PDF]
, 2010 In September 2007, three schools at Northumbria University came together in collaboration to create a Masters Programme in Multidisciplinary Design Innovation (MDI).
Bailey, Mark
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