Results 101 to 110 of about 5,395,832 (304)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 1982 Published since 1981, Engineers' Forum is Virginia Tech's interdisciplinary student-staffed engineering magazine. It covers the latest updates and articles regarding the achievements and initiatives of the Virginia Tech engineering community and the ...
Virginia Polytechnic Institute and State University. Student Engineers' Council
core
Engineering and reverse-engineering morality.
, 2021 Recent years have witnessed a burst of progress on building formal models of moral decision-making. In psychology, neuroscience and philosophy, the goal has been to “reverse-engineer” the principles of human morality. Meanwhile, in AI ethics, the goal has been to engineer systems that can make moral decisions, in some ways inspired by how humans do ...
Levine, Sydney +3 more
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Модернизация, инновация, развитие, 2015 A structural analysis of macroeconomic dynamics of the OECD countries andRussiain 1970–2008 has allowed to detect the main problem of Russian economy connected with the accumulated structural disproportions.
A. A. Akaev
doaj
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
, 1988 Published since 1981, Engineers' Forum is Virginia Tech's interdisciplinary student-staffed engineering magazine. It covers the latest updates and articles regarding the achievements and initiatives of the Virginia Tech engineering community and the ...
Virginia Polytechnic Institute and State University. Student Engineers' Council
core
The Chemical Weapons Convention and the Role of Engineers and Scientists [PDF]
Kemija u Industriji, 2010 Chemical weapons, like all military technology, are associated with activities of scientists and engineers. However, chemical weapons differ from any other military technology because they were invented, and their first mass use directly developed by ...
Matoušek, J
doaj
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source