Results 51 to 60 of about 5,881 (205)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

ESL Writing: Past, Present, and Future

open access: yesHOW, 2016
I would like to begin by telling you about the educational context that I work in because I think it tells you a lot about me and my thinking. I am a faculty member in the English Department at Purdue University in West Lafayette, Indiana in the USA ...
Tony Silva
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Motivation in ESL: A Literature Review

open access: yesCanadian Journal for New Scholars in Education, 2012
Motivation in second language acquisition (SLA) refers to the attempt and desire to learn a language and positive attitudes toward learning it (Dornyei, 1994).
Naghmeh Babaee
doaj  

Vocabulary Instruction for English Learners: A Systematic Review Connecting Theories, Research, and Practices

open access: yesEducation Sciences
Vocabulary instruction is pivotal to literacy development. While extensive research has been conducted, few studies have examined how research translates into practice and how theory informs it.
Yanfang Zeng   +4 more
doaj   +1 more source

LEARNING ENGLISH LANGUAGE AS A SECOND LANGUAGE

open access: yes, 2023
English is an international language which is used officially all around the world. English can connect society with the full world. Everyone who wants to make connections with the world should learn English. In our country learn English is necessary to reach some targets.
Isanova Sayyora Ilhomovna   +1 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Technological resources in the language classroom: managing time, levels and students’ autonomy

open access: yesLínguaTec, 2018
This narrative intends to describe tools that are being implemented in English Language classrooms, with public high school students in the Federal Institute of Rio Grande do Sul (IFRS), Campus Bento Gonçalves, in Brazil.
Elisa Seerig
doaj   +1 more source

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