Results 61 to 70 of about 10,087,447 (327)

Impact of interaction style and degree on the evolution of cooperation on Barabási-Albert scale-free network. [PDF]

PLoS ONE, 2017
In this work, we study an evolutionary prisoner's dilemma game (PDG) on Barabási-Albert scale-free networks with limited player interactions, and explore the effect of interaction style and degree on cooperation.
Fengjie Xie, Jing Shi, Jun Lin
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Determinants of public cooperation in multiplex networks

New Journal of Physics, 2017
Synergies between evolutionary game theory and statistical physics have significantly improved our understanding of public cooperation in structured populations.
Federico Battiston, Matjaž Perc, Vito Latora   +2 more
doaj   +1 more source

Enhanced Chelate Cooperativity in Polar Solvents

Journal of the American Chemical Society, 2017
High-throughput UV-vis titrations in combination with chemical double-mutant cycles (DMCs) have been used to study the competition of a polar solvent for formation of intramolecular H-bonds. Twenty-four different zinc porphyrin-pyridine complexes were investigated in mixtures of toluene and phenol.
Stefan Henkel, Maria Cristina Misuraca, Yudi Ding, Maxime Guitet, Christopher A. Hunter   +4 more
openaire   +2 more sources

Optimising the Mechanism for ‘Enhanced Cooperation’ within the EU: Recommendations for the Constitutional Treaty. CEPS Policy Brief No. 33, May 2003 [PDF]

, 2003
[Executive Summary]. Policy development in the EU is often impeded by member states being either unwilling or unable to participate. One way to overcome that problem is to resort to flexible approaches accommodating diversity.
Philippart, Eric.
core  

Cooperation enhanced by inhomogeneous activity of teaching for evolutionary Prisoner's Dilemma games

, 2006
Evolutionary Prisoner's Dilemma games with quenched inhomogeneities in the spatial dynamical rules are considered. The players following one of the two pure strategies (cooperation or defection) are distributed on a two-dimensional lattice.
A Szolnoki, Cressman R., G Szabó, Gintis H., Marro J., Perc M., Perc M., Perc M., Szabó G., Vainstein M. H. Silva A. T. C. Arenzon J. J., Weibull J. W., Wu Z.-X.   +11 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Book Review: Michael Baun and Dan Marek (eds.) The New Member States and the European Union. Foreign Policy and Europeanization [PDF]

Romanian Journal of European Affairs, 2014
A radical decision at the time, the 2004 enlargement constituted a critical juncture for the Central and Eastern European Countries. Although a great deal of literature has been written in regard to other aspects of Europeanization, the effects of EU ...
Adelin Dumitru
doaj  

Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities

Life, 2019
Microbial cooperation pervades ecological scales, from single-species populations to host-associated microbiomes. Understanding the mechanisms promoting the stability of cooperation against potential threats by cheaters is a major question that only ...
Daniel Rodríguez Amor, Martina Dal Bello   +1 more
doaj   +1 more source