Results 91 to 100 of about 8,887,574 (403)
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Genes & Development, 1994 Previously, we have isolated and characterized an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that directs high-level adipocyte-specific gene expression in both cultured cells and transgenic mice.
P. Tontonoz +4 more
semanticscholar +1 more source
Large-scale discovery of enhancers from human heart tissue. [PDF]
, 2011 Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers.
Afzal, Veena +16 more
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene
Journal of Developmental BiologyHox genes encode transcription factors whose roles in patterning animal body plans during embryonic development are well-documented. Multiple studies demonstrate that Hox genes continue to act in adult cells, in normal differentiation, in regenerative ...
Stephania A. Cormier, Claudia Kappen
doaj +1 more source
Shared enhancer gene regulatory networks between wound and oncogenic programs
eLife, 2023 Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay +14 more
doaj +1 more source
Enhancer features that drive formation of transcriptional condensates
bioRxiv, 2018 Enhancers, DNA elements that regulate gene expression, contain transcription factor (TF) binding sites. TFs bind short sequence motifs that are present throughout the genome at much higher frequency than active enhancers, and so the features that define ...
Krishna Shrinivas +10 more
semanticscholar +1 more source
NF-KB protein purification from bovine spleen: Nucleotide stimulation and binding site specificity [PDF]
, 1988 The activity of the enhancer for the κ immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-κB protein. We purified NF-κB over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and ...
Baltimore, David +3 more
core
Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]
, 1993 Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael +2 more
core +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Endogenous retroviral solo-LTRs in human genome
Frontiers in GeneticsHuman endogenous retroviruses (HERVs) are derived from the infection and integration of exogenetic retroviruses. HERVs account for 8% of human genome, and the majority of HERVs are solitary LTRs (solo-LTRs) due to homologous recombination.
Mingyue Chen +9 more
doaj +1 more source