Results 151 to 160 of about 8,934,200 (403)

The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription

Genes & Development, 2018
Here, Mikhaylichenko et al. investigate the transcriptional properties of enhancers during Drosophila embryogenesis using characterized developmental enhancers.
O. Mikhaylichenko, V. Bondarenko, Dermot Harnett, Ignacio E Schor, M. Maleš, R. R. Viales, E. Furlong   +6 more
semanticscholar   +1 more source

Technology Enhanced Technology Enhanced Learning [PDF]

Je-LKS: Journal of E-Learning and Knowledge Society, 2010
The application of modern technologies in education does not necessarily lead to positive results. An important factor is how these technologies are used. This paper describes some ideas about using technology to enhance Technology Enhanced Learning itself.
openaire   +2 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression

Cell Reports, 2020
Summary: NF-κB is a transcription factor that activates super enhancers (SEs) and typical enhancers (TEs) and triggers threshold and graded gene expression, respectively.
Hiroki Michida, Hiroaki Imoto, Hisaaki Shinohara, Noriko Yumoto, Masahide Seki, Mana Umeda, Tetsutaro Hayashi, Itoshi Nikaido, Takeya Kasukawa, Yutaka Suzuki, Mariko Okada-Hatakeyama   +10 more
doaj  

XXVIII. Observations and experiments on the occurrence of spark lines (enhanced lines) in the arc.—Part I. Lead and tin [PDF]

, 1922
G.A. Hemsalech, Arnaud de Gramont
openalex   +1 more source

Enhancer Redundancy Allows for Phenotypic Robustness in Mammalian Development

Nature, 2017
Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber protein-coding genes in mammalian genomes, but the functional importance of this regulatory complexity remains unclear. Here we show that the pervasive presence of
M. Osterwalder, I. Barozzi, Virginie Tissieres, Yoko Fukuda-Yuzawa, B. Mannion, Sarah Y. Afzal, Elizabeth Lee, Yiwen Zhu, I. Plajzer-Frick, C. Pickle, Momoe Kato, Tyler H. Garvin, Quan T. Pham, Anne N. Harrington, J. Akiyama, Veena Afzal, J. López-Ríos, D. Dickel, A. Visel, L. Pennacchio   +19 more
semanticscholar   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Identification and characterization of two critical sequences in SV40PolyA that activate the green fluorescent protein reporter gene

Genetics and Molecular Biology, 2011
Alu repeats or Line-1-ORF2 (ORF2) inhibit expression of the green fluorescent protein (GFP) gene when inserted downstream of this gene in the vector pEGFP-C1.
Honggang Wang, Wuzhuang Sun, Zhu Li, Xiufang Wang, Zhanjun Lv   +4 more
doaj  

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. [PDF]

, 2016
Cytochrome P450 (CYP) 1A1 is a phase I enzyme that can activate various compounds into reactive forms and thus, may contribute to carcinogenesis. In this study, we investigated the expression, methylation status, and functional role of CYP1A1 on prostate
Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hashimoto, Yutaka, Imai-Sumida, Mitsuho, Kato, Taku, Majid, Shahana, Mitsui, Yozo, Nakajima, Koichi, Saini, Sharanjot, Shiina, Hiroaki, Shiina, Marisa, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro   +15 more
core   +1 more source

Researches upon brown coals and ignites. Part I.— Heat treatment at temperatures below 400° C. as a possible method for enhancing their fuel values [PDF]

, 1921
William Arthur Bone
openalex   +1 more source