Results 211 to 220 of about 293,755 (268)

STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy. [PDF]

iScience
Becker R, Choudhury P, Oti M, Fouani Y, Strobel B, Ketterer S, Rumpel S, Park J, Kreuz S, Maier U, Michelfelder S, Schön C.   +11 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis. [PDF]

Nat Commun
Cetnarowska A, Hyldahl M, Nygård M, Dashti H, Hansen BV, Holm LK, Madsen K, Madsen MS, Shukla V, Durmaz Mitchell E, Rauch A, Madsen JGS, Claussnitzer M, Mandrup S.   +13 more
europepmc   +1 more source

A Conserved Enhancer Locus in Extrachromosomal DNA and Homogeneously Staining Regions Activates MYC Transcription in Group 3 Medulloblastoma. [PDF]

Cancer Res
Friske JD, Cuisin F, Guernalec P, Malone HA, Nance S, Bennett D, Burden SJ, Chang TC, Shi H, Williams JS, Valentine V, Passaia BDS, Ju B, Adetunji MO, Geeleher P, Abraham BJ, Wu G, Li C, Roussel MF.   +18 more
europepmc   +1 more source

Distal enhancers loop to proximal enhancers, not to promoters

Nature Reviews Molecular Cell Biology
openaire   +3 more sources

Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications. [PDF]

Front Immunol
Deng M, Lin Y, Fang C, Cai J, Chen C, Ding J.   +5 more
europepmc   +1 more source

Massively parallel reporter assay-informed modeling improves prediction of context-specific enhancer-gene regulatory interactions. [PDF]

Nucleic Acids Res
DeGroat W, Kreimer A.
europepmc   +1 more source

MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription. [PDF]

NAR Cancer
Kalyan Sundaram R, Parihar K, Monson S, Radhakrishnan R, Lim B.   +4 more
europepmc   +1 more source

MYC-bound enhancer RNAs in cis regulate gene transcription and tumorigenesis. [PDF]

Sci Adv
Li S, Wang Z, Nguyen P, Wang Y, Zhao Y, Wang Y, Chen Y, Huang H, Wang X, Zhang Y, Huang Y, Pattarayan D, Zhang M, Liu Y, Li S, Yang D.   +15 more
europepmc   +1 more source