Results 221 to 230 of about 2,230,930 (359)

Identification of super-enhancer-based biomarkers for predicting survival and immunotherapy efficacy in colorectal cancer. [PDF]

J Cancer
Yu Y, Zhang X, Ma X, Ren J, Zhang J, Zhu L, Chen Y, Lu Z, Li J.   +8 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An EGR1-dependent cascade modulates genome architecture at the CSF1R locus. [PDF]

Nucleic Acids Res
Deliard S, Barbieri E, Trizzino M, Leach KA, Zucco A, Picone F, Veglia F, Gardini A.   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

ELK4 Promotes Vasculogenic Mimicry in Oral Squamous Cell Carcinoma via Driving <i>DHFR</i> Transcriptional Activation. [PDF]

Oncol Res
Qiu Y, Li K, Wang W, Zhang W, Liu J, Bai Y, Xu F, Guo J.   +7 more
europepmc   +1 more source

Enhanced Infrared Vision by Nonlinear Up‐Conversion in Nonlocal Metasurfaces [PDF]

Laura Valencia Molina, Rocio Camacho‐Morales, Jihua Zhang, Roland Schiek, Isabelle Staude, Andrey A. Sukhorukov, Dragomir N. Neshev   +6 more
openalex   +1 more source

Enhanced imaging [PDF]

Colorectal Disease, 2015
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation. [PDF]

Theranostics
Mao L, Liao ZF, Tang D, Qiu Y, Yang M, Li Y, Xie Y, Feng W, Zheng ZJ, Liu XM, Ye JR, Lu SH, Tang XB, Shi M, Qu YF, Li H, Wu ZG, Xu S, Liu X, Ding J, Xie JJ, Tao J, Xiong XD.   +22 more
europepmc   +1 more source

Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT1A receptor sensitivity

, 2019
D Peeters, Sietse F. de Boer, Anneke Terneusen, Adrian Newman‐Tancredi, Mark A. Varney, Robbert‐Jan Verkes, Judith R. Homberg   +6 more
openalex   +2 more sources