Results 221 to 230 of about 8,934,200 (403)

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Cell, 2014
Yonit Lavin, D. Winter, Ronnie Blecher-Gonen, Eyal David, Hadas Keren-Shaul, M. Merad, Steffen Jung, I. Amit   +7 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

Nature Structural & Molecular Biology, 2019
Sreejith J. Nair, Lu Yang, Dario Meluzzi, Soohwan Oh, Feng Yang, Meyer J. Friedman, Susan Wang, Tom Suter, Ibraheem Alshareedah, A. Gamliel, Qi Ma, Jie Zhang, Yi-ren Hu, Yuliang Tan, K. Ohgi, R. Jayani, Priya R Banerjee, A. Aggarwal, M. Rosenfeld   +18 more
semanticscholar   +1 more source

To scan or not to scan, to enhance or not to enhance? That is the question [PDF]

Hong Kong Medical Journal, 2014
Lily Li, Jonathan Costello
openaire   +3 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Enhancement of the Pathogenicity of Mouse Hepatitis Virus (MHV1) By Prior Infection of Mice with Certain Leukaemia Agents [PDF]

, 1961
A. W. Gledhill
openalex   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Uncovering hidden enhancers through unbiased in vivo testing. [PDF]

Nat Commun
Mannion BJ, Tran S, Plajzer-Frick I, Novak CS, Afzal V, Akiyama JA, Sospedra-Arrufat I, Barton S, Beckman E, Garvin TH, Godfrey P, Godoy J, Hunter RD, Kato M, Kosicki M, Kronshage AN, Lee EA, Meky EM, Pham QT, von Maydell K, Zhu Y, Lopez-Rios J, Dickel DE, Osterwalder M, Visel A, Pennacchio LA.   +25 more
europepmc   +1 more source

Enhanced Deoxyribonucleic Acid Polymerase Activity in Human Embryonic Kidney Cultures Infected with Adenovirus 2 or 12 [PDF]

, 1968
Nada Ledinko
openalex   +1 more source

Systematic mapping of functional enhancer–promoter connections with CRISPR interference

Science, 2016
C. Fulco, Mathias Munschauer, Rockwell Anyoha, Glen Munson, S. Grossman, Elizabeth M. Perez, Michael Kane, B. Cleary, E. Lander, J. Engreitz   +9 more
semanticscholar   +1 more source