Results 281 to 290 of about 8,934,200 (403)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q. [PDF]

Blood Cancer Discov
Sollier E, Riedel A, Toprak UH, Wierzbinska JA, Weichenhan D, Schmid JP, Hakobyan M, Touzart A, Jahn E, Vick B, Brown-Burke F, Kelly K, Kelekçi S, Pejkovska A, Goyal A, Bähr M, Breuer K, Chen MM, Llamazares-Prada M, Hartmann M, Schönung M, Correia N, Trumpp A, Abdullah Y, Klingmüller U, Mughal SS, Brors B, Westermann F, Ulrich E, Autry RJ, Schlesner M, Vosberg S, Herold T, Greif PA, Pfeifer D, Lübbert M, Fischer T, Heidel FH, Gebhard C, Walter W, Haferlach T, Eisfeld AK, Mrózek K, Nicolet D, Bullinger L, Smeenk L, Erpelinck-Verschueren C, Mulet-Lazaro R, Delwel R, Ernst A, Scherer M, Lutsik P, Jeremias I, Döhner K, Döhner H, Lipka DB, Plass C.   +56 more
europepmc   +1 more source

RNA induced enhancement of a simple discrimination task [PDF]

, 1968
Robert G. Gibby, David G. Crough, Samuel J. Twios   +2 more
openalex   +1 more source

Enhancer Evolution across 20 Mammalian Species

Cell, 2015
D. Villar, Camille Berthelot, S. Aldridge, Tim F. Rayner, M. Lukk, M. Pignatelli, T. Park, R. Deaville, J. T. Erichsen, A. Jasinska, James M. A. Turner, M. Bertelsen, E. Murchison, Paul Flicek, D. Odom   +14 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

H3K4me2 distinguishes a distinct class of enhancers during the maternal-to-zygotic transition. [PDF]

PLoS Biol
Hurton MD, Miller JM, Lee MT.
europepmc   +1 more source

Long Noncoding RNAs with Enhancer-like Function in Human Cells

Cell, 2010
U. A. Ørom, T. Derrien, M. Beringer, Kiranmai Gumireddy, Alessandro Gardini, G. Bussotti, F. Lai, M. Zytnicki, Cédric Notredame, Qihong Huang, R. Guigó, R. Shiekhattar   +11 more
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

A Coronal Enhancement in the Extreme Ultraviolet

, 1969
William J. Boardman, Donald E. Billings
openalex   +1 more source

Enhancer–promoter interactions are encoded by complex genomic signatures on looping chromatin

Nature Genetics, 2016
Sean Whalen, R. Truty, K. Pollard
semanticscholar   +1 more source