Results 51 to 60 of about 8,887,574 (403)
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]
, 2020 Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W +14 more
core +2 more sources
Typical Enhancers, Super-Enhancers, and Cancers
Cancers, 2022 Non-coding segments of the human genome are enriched in cis-regulatory modules that constitute functional elements, such as transcriptional enhancers and Super-enhancers. A hallmark of cancer pathogenesis is the dramatic dysregulation of the “archetype” gene expression profiles of normal human cells.
Marianna A. Koutsi +6 more
openaire +2 more sources
Transcriptional complex assembly represented in SBGN PD [PDF]
, 2010 This poster shows how transcriptional complex assembly can be represented in SBGN Process Description language.
Alexander Mazein +2 more
core +2 more sources
Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals [PDF]
, 2016 Regulatory regions in the genome can act through a variety of mechanisms that range from the occurrence of histone modifications to the presence of protein-binding loci for self-annealing sequences.
Cacchione, Stefano +9 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2016 Transvection—pairing-dependent interallelic regulation resulting from enhancer action in trans—occurs throughout the Drosophila melanogaster genome, likely as a result of the extensive somatic homolog pairing seen in Dipteran species.
Geoffrey P. Noble +2 more
doaj +1 more source
Enhancing the durational enhancement of a tone contrast [PDF]
The Journal of the Acoustical Society of America, 2006 In central and low Franconian dialects of German and Dutch, a lexical tone contrast (accent 1 versus accent 2) exists that is enhanced by a durational difference. While pitch differences vary according to intonation and sentence context, syllables are generally shorter when they have accent 1.
openaire +6 more sources
Epigenomics, 2018 Enhancers are short noncoding segments of DNA (100-1000 bp) that control the temporal and spatial activity of genes in an orientation-independent manner. They can be separated from their target genes by large distances and are thus known as distal regulatory elements.
Snetkova, Valentina, Skok, Jane A
openaire +4 more sources
The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression
Cell Reports, 2020 Summary: NF-κB is a transcription factor that activates super enhancers (SEs) and typical enhancers (TEs) and triggers threshold and graded gene expression, respectively.
Hiroki Michida +10 more
doaj
Frontiers in Immunology, 2018 The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis.
Haeja Kessler +3 more
doaj +1 more source
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini A., Minerva F.
openaire +3 more sources