Results 61 to 70 of about 8,887,574 (403)

Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency

Stem Cell Reports, 2016
Naive and primed pluripotent stem cells (PSCs) and germ cells express the Oct4 gene. The Oct4 gene contains two cis-regulatory elements, the distal enhancer (DE) and proximal enhancer (PE), which differentially control Oct4 expression in a cell-type ...
Hyun Woo Choi, Jin Young Joo, Yean Ju Hong, Jong Soo Kim, Hyuk Song, Jeong Woong Lee, Guangming Wu, Hans R. Schöler, Jeong Tae Do   +8 more
doaj   +1 more source

Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis

Frontiers in Genetics, 2023
Background: Hepatocellular carcinoma (HCC) remains notorious for its high malignancy, poor prognosis and high mortality. The exploration of novel therapeutic agents for HCC has remained challenging due to its complex aetiology. Therefore, it is necessary
Jianing Yan, Jianing Yan, Guoliang Ye, Guoliang Ye, Yongfu Shao, Yongfu Shao, Hanxuan Zhou   +6 more
doaj   +1 more source

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries [PDF]

, 2012
Epigenomic profiling has revealed that substantial portions of genomes in higher eukaryotes are organized into extensive domains of transcriptionally repressive chromatin.
Adam G West, Faust, Gomos-Klein, Gráinne Barkess, Hadjur, Hawkins, Hebbes, Ortiz, Roseman, Scott   +9 more
core   +1 more source

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

Antibodies, 2018
The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation.
Chuan Chen, Jie Wang, Yun Zhao, Shaopeng Chen, Zhishang Hu, Long Chen, Haiying Hang   +6 more
doaj   +1 more source

Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Proper function of endothelial cells is critical for vascular integrity and organismal survival. Studies over the past 2 decades have identified 2 members of the KLF (Krüppel‐like factor) family of proteins, KLF2 and KLF4, as nodal regulators ...
David R. Sweet, Roshan Padmanabhan, Xudong Liao, Himanshu R. Dashora, Xinmiao Tang, Lalitha Nayak, Rajan Jain, Sarah De Val, Vinesh Vinayachandran, Mukesh K. Jain   +9 more
doaj   +1 more source

Identification and Analysis of Conserved cis-Regulatory Regions of the MEIS1 Gene [PDF]

, 2012
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variety of tissues during development. Its complex expression pattern is likely to be controlled by an equally complex regulatory landscape.
Bessa, José, Casares, Fernando, Fernández-Miñán, Ana, Gómez-Skarmeta, José Luis, Hidalgo, Carmen, Roncero, Yolanda, Royo Sánchez-Palencia, José Luis, Tena Aguilar, Juan Jesús   +7 more
core   +6 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma

Molecular Therapy: Nucleic Acids, 2021
Glioma is the most common malignancy in the central nervous system with no immediate prospect of a cure. Comprehensive understanding on the pathogenesis of the disorder contributes to a better outcome.
Meixiong Cheng, Yi Zeng, Tian Zhang, Min Xu, Zhili Li, Yaqiu Wu   +5 more
doaj  

FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer–gene programs in basal-like breast cancer

Frontiers in Oncology, 2023
Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa, Liying Yang, Kenichi Miyata, Reo Maruyama, Reo Maruyama   +4 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source