Results 121 to 130 of about 4,995,766 (296)

Additional file 3 of Genetic effects of sequence-conserved enhancer-like elements on human complex traits

Additional file 3. Review history.
Zhu, Xiang, Ma, Shining, Wong, Wing Hung
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

, 2020
Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in response
Lothar Hennighausen, Jakub Jankowski, Takaharu Ichimura, Michaela Willi, Hannes Olauson, Hye Kyung Lee, Julia Wilflingseder, Reinhold Erben, M. Todd Valerius, Joseph V. Bonventre, Willi, M, Valerius, MT, Bonventre, JV, Jankowski, J, Olauson, H,, Wilflingseder, J, Ichimura, T, Erben, R, Hennighausen, L, Lee, HK   +19 more
core   +1 more source

Enhancement of Wear Resistance of High-Load Pressing Screw in Smokeless Charcoal Production by Using Genetic Algorithm and Discrete Element Method

Tribology in Industry
During the production of smokeless charcoal, the pressing screw of the sawdust compressor is exposed to the effects of friction and elevated temperature, resulting in rapid wear. This phenomenon not only diminishes productivity but also exerts adverse influences on the final product's quality.
Hong Tien Nguyen, Tuan-Linh Nguyen, Nguyen Van Thien, Phan Van Quoc   +3 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chromatin Structures of the Rat Tyrosine Aminotransferase Gene Relate to the Function of Its cis-Acting Elements [PDF]

, 1990
The relationship between DNase I-hypersensitive sites (HSs) and transcriptional enhancers of the rat tyrosine aminotransferase (TAT) gene was examined by comparing HSs in and around the TAT gene with the activity of the corresponding DNA sequences in ...
Boshart, Michael, Schütz, Günther, Nitsch, Doris, Mestril, Ruben, Weih, Falk, Stewart, A. F.   +5 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Shape Sensing in Plate Structures through Inverse Finite Element Method Enhanced by Multi-Objective Genetic Optimization of Sensor Placement and Strain Pre-Extrapolation

Sensors
The real-time reconstruction of the displacement field of a structure from a network of in situ strain sensors is commonly referred to as “shape sensing”. The inverse finite element method (iFEM) stands out as a highly effective and promising approach to perform this task.
Emiliano Del Priore, Luca Lampani
openaire   +5 more sources