Results 111 to 120 of about 4,995,766 (296)
Changes in Cis-regulatory Elements during Morphological Evolution
Biology, 2012 How have animals evolved new body designs (morphological evolution)? This requires explanations both for simple morphological changes, such as differences in pigmentation and hair patterns between different Drosophila populations and species, and also ...
Yu-Lee Paul, Stephen J. Gaunt
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
iScienceSummary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk.
Romina J. Bevacqua +6 more
doaj +1 more source
Assessing eRNAs associated with a cytokine-sensing mammary super-enhancer
, 2017 Enhancers are transcription factor platforms that also bind RNA polymerase II and generate enhancer RNAs (eRNA). Although eRNAs have been suggested as predictors of enhancer activities and possibly key components facilitating transcription, there is ...
Christian Reinbold +4 more
core +1 more source
Additional file 2: Supplementary information. This file includes Supplementary Notes 1-4, legends for Supplementary Tables 1-26, and Supplementary Figures 1-16.
Zhu, Xiang, Ma, Shining, Wong, Wing Hung
openaire +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PLoS ONEEnhancers are critical regulatory DNA elements that, when dysregulated, can contribute to disease pathogenesis by altering gene expression. Although millions of enhancers have been identified through large-scale genomic projects, their associations with ...
Duc-Hau Le
doaj +1 more source
, 2018 Liming Huang,1 Wenshen Xu,2 Lian Dai,3 Danfang Yan,4 Shu Zhang,1 Xi Shi1 1The First Department of Chemotherapy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China; 2Department of Laboratory Medicine, The First Affiliated ...
Dai L +5 more
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