Results 91 to 100 of about 4,995,766 (296)

Enhancer reprogramming in mammalian genomes

BMC Bioinformatics, 2018
Background Transcription factor binding site (TFBS) loss, gain, and reshuffling within the sequence of a regulatory element could alter the function of that regulatory element.
Mario A. Flores, Ivan Ovcharenko
doaj   +1 more source

Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene [PDF]

, 1989
In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the ...
Lubon, H, Hennighausen, L, Nelson, J, Reynolds-Kohler, C, Ghazal, Peter, Lockshin, C, Ghazal, P   +6 more
core   +1 more source

Genetic polymorphisms in the RNA polymerase II core promoter and enhancer elements of the UGT1A1 promoter influence activation of its gene transcription

The FASEB Journal, 2008
RNA polymerase II core promoter and enhancer/repressor elements are involved in regulation of gene transcription. The objective of this study is to examine whether genetic polymorphisms in these elements can change regulation of gene transcription. Genetic polymorphisms in the UGT1A1 promoter were evaluated, which include polymorphism of (TA)6/7TAA (*1/
Ye Li, David Buckley, Shuang Wang, Steven N. Hart, Kaori Nakamoto, Curtis D. Klaassen, Xiaobo Zhong   +6 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex

, 2002
Insulator DNAs and promoter competition regulate enhancer–promoter interactions within complex genetic loci. Here we provide evidence for a third mechanism: promoter-proximal tethering elements.
Michael Levine, Vincent C. Calhoun, Angelike Stathopoulos   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Post-GWAS era in genetics of schizophrenia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
Genome-wide association studies (GWASs) discovered multiple genetic variants associated with schizophrenia. Te next step (post-GWAS analysis) is aimed at identifying the causal genetic variants and biological mechanisms underlying the associations with ...
V. E. Golimbet, A. K. Golov, N. V. Kondratyev   +2 more
doaj   +1 more source