Results 81 to 90 of about 88,833 (257)
Genetic determinants of enhancer function
, 2022 Sequence variation in enhancers, a class of cis-regulatory elements (CREs) that control cell type-specific gene transcription, contributes significantly to phenotypic variation within human populations, including the risk of developing diseases ...
Yang, Marty Gilman
core
Post-GWAS era in genetics of schizophrenia
Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019 Genome-wide association studies (GWASs) discovered multiple genetic variants associated with schizophrenia. Te next step (post-GWAS analysis) is aimed at identifying the causal genetic variants and biological mechanisms underlying the associations with ...
V. E. Golimbet +2 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Implications of enhancer transcription and eRNAs in cancer
, 2021 Despite extensive progress in developing anti-cancer therapies, therapy resistance remains a major challenge that promotes disease relapse. The changes that lead to therapy resistance can be intrinsically present or may be initiated during treatment ...
Chacon, Jessica +4 more
core +1 more source
Enhancer dysfunction in leukemia
, 2018 Hematopoietic cancers are often initiated by deregulation of the transcriptional machinery. Prominent among such regulators are the sequence-specific DNA-binding transcription factors (TFs), which bind to enhancer and promoter elements in the genome to ...
Anand S. Bhagwat +2 more
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
PLoS Pathogens, 2015 Viral engagement with macrophages activates Toll-Like-Receptors (TLRs) and viruses must contend with the ensuing inflammatory responses to successfully complete their replication cycle.
Kai A Kropp +7 more
doaj +1 more source
Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
Frontiers in Molecular Neuroscience, 2018 Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap ...
Martin Becker +6 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity [PDF]
, 2013 The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would ...
Salomone, Joseph R. +28 more
core +1 more source