Results 231 to 240 of about 88,833 (257)

A Conserved Enhancer Locus in Extrachromosomal DNA and Homogeneously Staining Regions Activates MYC Transcription in Group 3 Medulloblastoma. [PDF]

Cancer Res
Friske JD, Cuisin F, Guernalec P, Malone HA, Nance S, Bennett D, Burden SJ, Chang TC, Shi H, Williams JS, Valentine V, Passaia BDS, Ju B, Adetunji MO, Geeleher P, Abraham BJ, Wu G, Li C, Roussel MF.   +18 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

LRP1 in atherosclerosis: a hierarchical view of regulatory mechanisms and epigenetic knowledge gaps. [PDF]

Front Cell Dev Biol
Casale R, Chiabrando GA, Ceschin DG.
europepmc   +1 more source

EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles. [PDF]

Nat Commun
Lin J, Li Z, Zhao Y, Luo R, Pinello L.
europepmc   +1 more source

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes. [PDF]

Nat Commun
Haydar S, Bednarz R, Laurette P, Sobitov I, Díaz I Pedrosa N, Videm P, Lueneburg T, Kuß S, Lahm H, Dreßen M, Krane M, Schmidt C, Grüning BA, Voigt N, Streckfuss-Bömeke K, Gilsbach R.   +15 more
europepmc   +1 more source

HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma. [PDF]

Nat Commun
Naas S, Krüger R, Grampp S, Lauer V, Kraus A, Naas J, Müller F, Gsottberger F, Schiffer M, Wullich B, Hartmann A, Stemmler MP, Schödel J.   +12 more
europepmc   +1 more source

Elastic enhancer network tunes equilibrium thermodynamics of liquid liquid phase separation in super enhancers. [PDF]

iScience
Guo T, Zhang N, Li Y, Hao S, Liu J, Zhang L.   +5 more
europepmc   +1 more source

<i>ROBO2</i> Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element. [PDF]

Circ Genom Precis Med
Kim SW, Parfenov M, Rodriguez-Murillo L, Conner DA, Sharma A, Peter I, Xiao F, Layton O, Tai A, Ward T, Wasson LK, Gorham JM, Mazaika E, Lagomarsino VN, Young-Pearse TL, Goldmuntz E, Wakimoto H, Agopian AJ, McKean DM, DePalma SR, Pu WT, Seidman CE, Gelb BD, Seidman JG, PCGC Investigators.   +24 more
europepmc   +1 more source

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Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction

Circulation, 2021
Joyce C K Man, Roddy Walsh, Connie R Bezzina   +2 more
exaly  

Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

Gene, 2023
Yoshiaki Itô, Motomi Osato
exaly