Results 151 to 160 of about 79,525 (194)

Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital

European Journal of Pharmacology, 1982
In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
G, Sander, T, Giles, A, Kastin, A, Kaneish, D, Coy   +4 more
openaire   +2 more sources

Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid

1983
Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
T.O. KLEINE, B. MERTEN, A. SINGH
openaire   +1 more source

Intraventricular self-administration of leucine-enkephalin by laboratory rats

Life Sciences, 1982
Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
B R, Smith, Z W, Brown, Z, Amit
openaire   +2 more sources

Brain methionine- and leucine-enkephalin receptors in patients with dementia

Neuroscience Letters, 1993
Brain [3H]Met- and [3H]Leu-enkephalin binding was studied in patients with Alzheimer's disease (AD) and vascular dementia (VD), and in age-matched controls. Brain areas investigated were the internal and external globus pallidus, amygdala, hippocampus and temporal cortex.
J O, Rinne, P, Lönnberg, P, Marjamäki, P, Mölsä, E, Säkö, L, Paljärvi   +5 more
openaire   +2 more sources

Age Increases Leucine Enkephalin Hydrolysis in Human Plasma

Gerontology, 1998
<i>Background:</i> The existence of age-associated alterations in immune functions and neuropeptides capable of modulating these functions prompted us to advance the hypothesis that the degradation of plasma neuropeptides, specifically opioid peptides, may be altered by aging.
L, Bongiorno, M, Marzano, M, Marini, L G, Roda, A, Urbani, G, Spagnoli   +5 more
openaire   +2 more sources

Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma

The Journal of Pharmacology and Experimental Therapeutics, 1999
Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (proximal femur fracture); data obtained were compared with those obtained in an age-matched control group.
R, Babst, L, Bongiorno, M, Marini, L G, Roda, G, Spagnoli, A, Urbani   +5 more
openaire   +2 more sources

Synthesis and biological activity of chloromethyl ketones of leucine enkephalin

Biochemical and Biophysical Research Communications, 1980
Summary The chloromethyl ketones of leucine enkephalin and D-Ala 2 -leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.
J T, Pelton, R B, Johnston, J L, Balk, C J, Schmidt, E B, Roche   +4 more
openaire   +2 more sources

Interactions of Leucine-enkephalin with α-Adrenoceptors in the Conscious Dog

Chest, 1983
Leucine-enkephalin (Leu-ENK) administered systemically to the conscious dog increases heart rate and blood pressure, a response prevented by naloxone and hence mediated by opiate receptors. Clonidine attenuates the heart rate increase without affecting the pressor response.
T D, Giles, G E, Sander
openaire   +2 more sources

Enzyme-linked immunosorbent assay for leucine and methionine enkephalins

Analytical Biochemistry, 1983
An enzyme-linked immunosorbent assay for enkephalins was developed by coupling the peptides to a carrier molecule (bovine serum albumin) in order to allow the antibody-antigen reaction to take place in the solid phase. The assay was shown to be highly reproducible.
G, Zamboni, C A, Jones, J, Hughes
openaire   +2 more sources

Synthesis and biological evaluation of leucine enkephalin turn mimetics

Organic & Biomolecular Chemistry, 2006
A cyclic Leu-enkephalin mimetic containing a 7-membered ring, and two linear analogues, has been prepared on solid phase. In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.
David, Blomberg, Paul, Kreye, Chris, Fowler, Kay, Brickmann, Jan, Kihlberg   +4 more
openaire   +2 more sources