Results 171 to 180 of about 20,669 (211)
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Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid
1983Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
T.O. KLEINE, B. MERTEN, A. SINGH
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Interactions of Leucine-enkephalin with α-Adrenoceptors in the Conscious Dog
Chest, 1983Leucine-enkephalin (Leu-ENK) administered systemically to the conscious dog increases heart rate and blood pressure, a response prevented by naloxone and hence mediated by opiate receptors. Clonidine attenuates the heart rate increase without affecting the pressor response.
T D, Giles, G E, Sander
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Synthesis of leucine enkephalin derivatives: Structure-function studies
Biochemical and Biophysical Research Communications, 1977Abstract The solid phase synthesis of highly purified [Leu 5 ] enkephalin and of seven derivatives including [Ala 2 ,Leu 5 ]-, [Ser 2 ,Leu 5 ]-, [Ser 3 ,Leu 5 ]-, [Aba 2 ,Leu 5 ]-, and [des-Gly 2(3) ,Leu 5 ]enkephalins are reported, and their morphine-like activities in neuroblastoma x glioma cell homogenates were measured. Changes at the 2, 3, and 5
N S, Agarwal +4 more
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Enzyme-linked immunosorbent assay for leucine and methionine enkephalins
Analytical Biochemistry, 1983An enzyme-linked immunosorbent assay for enkephalins was developed by coupling the peptides to a carrier molecule (bovine serum albumin) in order to allow the antibody-antigen reaction to take place in the solid phase. The assay was shown to be highly reproducible.
G, Zamboni, C A, Jones, J, Hughes
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Synthesis and biological evaluation of leucine enkephalin turn mimetics
Organic & Biomolecular Chemistry, 2006A cyclic Leu-enkephalin mimetic containing a 7-membered ring, and two linear analogues, has been prepared on solid phase. In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.
David, Blomberg +4 more
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Synthesis and biological activity of chloromethyl ketones of leucine enkephalin
Biochemical and Biophysical Research Communications, 1980Summary The chloromethyl ketones of leucine enkephalin and D-Ala 2 -leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.
J T, Pelton +4 more
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Age Increases Leucine Enkephalin Hydrolysis in Human Plasma
Gerontology, 1998<i>Background:</i> The existence of age-associated alterations in immune functions and neuropeptides capable of modulating these functions prompted us to advance the hypothesis that the degradation of plasma neuropeptides, specifically opioid peptides, may be altered by aging.
L, Bongiorno +5 more
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Leucine-enkephalin metabolism in brain microvessel endothelial cells
Peptides, 1994The metabolism of leucine-enkephalin was investigated in primary cultures of bovine brain microvessel endothelial cell (BMEC) monolayers. Leucine-enkephalin was hydrolyzed slowly with less than 40% of the peptide metabolized following a 5-h incubation with intact BMEC monolayers at 37 degrees C.
S E, Thompson, K L, Audus
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Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma
The Journal of Pharmacology and Experimental Therapeutics, 1999Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (proximal femur fracture); data obtained were compared with those obtained in an age-matched control group.
R, Babst +5 more
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Endogenous Signaling Complexity in Neuropeptides- Leucine- and Methionine-Enkephalin
Cellular and Molecular Neurobiology, 20061. In addition to his many fine contributions in furthering our understanding of the neurochemical action of ecosanoids, catchelomines, steroids, anandamines, cannabinoids, endorphins, and the many modifications made to these neural factors, twenty years ago Julius Axelrod published a noteworthy paper concerning the nature of neuropeptides and their ...
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