Results 171 to 180 of about 126,781 (219)

Age Increases Leucine Enkephalin Hydrolysis in Human Plasma

Gerontology, 1998
<i>Background:</i> The existence of age-associated alterations in immune functions and neuropeptides capable of modulating these functions prompted us to advance the hypothesis that the degradation of plasma neuropeptides, specifically opioid peptides, may be altered by aging.
L, Bongiorno, M, Marzano, M, Marini, L G, Roda, A, Urbani, G, Spagnoli   +5 more
openaire   +2 more sources

Microglial NADPH Oxidase Mediates Leucine Enkephalin Dopaminergic Neuroprotection

Annals of the New York Academy of Sciences, 2005
Abstract:Here, we report that leucine enkephalin (LE) is neuroprotective to dopaminergic (DA) neurons at femtomolar concentrations through anti‐inflammatory properties. Mesencephalic neuron‐glia cultures pretreated with femtomolar concentrations of LE (10−15‐10−13M) protected DA neurons from lipopolysaccharide (LPS)‐induced DA neurotoxicity, as ...
Liya, Qin, Yuxin, Liu, Xun, Qian, Jau-Shyong, Hong, Michelle L, Block   +4 more
openaire   +2 more sources

Glycation of Leucine-Enkephalin: Imidazolidinones and Amadori Compounds

2001
In an effort to elucidate the properties and reactivity of the parent free sugars, herein we present the formation of leucine-enkephalin related imidazolidinones, as well as Amadori compounds from glucose, mannose or galactose and leucine-enkephalin. We will present the influence of solvent , temperature and added base on the rate of formation of these
Horvat, Štefica, Roščić, Maja
openaire   +2 more sources

Plasma Methionine-Enkephalin and Leucine-Enkephalin in Normal Subjects and Patients with Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa, K, Nakao, S, Li, Y, Ikeda, M, Suda, M, Sakamoto, H, Imura   +6 more
openaire   +2 more sources

Methionine-enkephalin and leucine-enkephalin increase interleukin-1β release in mixed glia cultures

Neuropeptides, 2002
Interleukin-1 beta (IL-1 beta) is synthesized in the brain in response to LPS. Excessive IL-1 beta expression is observed in neurodegenerative diseases. The aim of this study was to evaluate the effects of methionine-enkephalin (ME) and leucine-enkephalin (LE) on the baseline and LPS-activated release of IL-1 beta in rat mixed glia cultures.
Jan, Kowalski, Bozena, Gabryel, Krzysztof, Łabuzek, Zbigniew S, Herman   +3 more
openaire   +2 more sources

The opioid peptide leucine-enkephalin disrupts seasonal and gonadotropin-induced ovarian recrudescence in the gecko Hemidactylus frenatus.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2023
Ananya Ganeyan, C. B. Ganesh
semanticscholar   +1 more source

Secondary ion mass spectra of the neuropeptides leucine-enkephalin and methionine-enkephalin

Biological Mass Spectrometry, 1982
Positive and negative secondary ion mass spectra obtained by bombardment of thin films of leucine-enkephalin and methionine-enkephalin with a pulsed beam of Cs+ ions of energy 5–15 keV were recorded using a time-of-flight mass spectrometer. Many of the secondary ions are metastable.
J. B. Westmore, W. Ens, K. G. Standing
openaire   +1 more source

Synthesis of [2,6-3H2-Tyr1]leucine-enkephalin

Journal of the Chemical Society, Perkin Transactions 1, 1990
The synthesis of [2,6-3H2-Tyr1]leucine-enkephalin by the catalytic tritiation of [2,6-dibromo-Tyr1]leucine-enkephalin is described. The precursor amino acid, 2,6-dibromo-DL-tyrosine, was synthesized in three steps from 2,6-dibromo-4-methoxytoluene.
Hiroshi Hasegawa, Nobuyoshi Akagawa, Yoshihiko Shinohara, Shigeo Baba   +3 more
openaire   +1 more source

Intraventricular self-administration of leucine-enkephalin by laboratory rats

Life Sciences, 1982
Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
B R, Smith, Z W, Brown, Z, Amit
openaire   +2 more sources

Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital

European Journal of Pharmacology, 1982
In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
G, Sander, T, Giles, A, Kastin, A, Kaneish, D, Coy   +4 more
openaire   +2 more sources