Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities
ChemMedChem, Volume 20, Issue 14, July 18, 2025.Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia +4 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka +5 more
wiley +1 more source
World Journal of Acupuncture - MoxibustionObjectives: Retinal ischemia-reperfusion (RIR) injury results in irreversible visual impairments. The disruption of the outer blood-retinal barrier (OBRB) is a major ocular pathogenic process that RIR injury affects.
Ping CHEN +7 more
doaj +1 more source
A Fast and Precise Method To Identify Indolic Glucosinolates and Camalexin in Plants by Combining Mass Spectrometric and Biological Information [PDF]
, 2012 In this manuscript, a fast and accurate identification and quantitation by mass spectrometry of indolic glucosinolates and camalexin involved in defense in Arabidopsis thaliana are described.
Arbona, Vicent, Gomez-Cadenas, Aurelio
core +2 more sources
Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor [PDF]
, 2015 Fluorescently labeled ligands are useful pharmacological research tools for studying receptor localization, trafficking, and signaling processes via fluorescence imaging. They are also employed in fluorescent binding assays. This study is centered on the
Briddon, Stephen J. +6 more
core +4 more sources
Molecular Aspect of Annelid Neuroendocrine system
, 2007 Hormonal processes along with enzymatic processing similar to that found in vertebrates occur in annelids. Amino acid sequence determination of annelids precursor gene products reveals the presence of the respective peptides that exhibit high sequence ...
Salzet, M.
core +1 more source
Studies on the small neuropeptide: RPCH and ENK, their function of reproductive regulation in the mud crab, Scylla paramamosain (Estampador, 1949) [PDF]
, 2013 拟穴青蟹（Scyllaparamamosain）是我国东南沿海重要的经济蟹类。本文以拟穴青蟹为研究对象，采用动物生理学、分子生物学、生物信息学等方法和手段，研究了3种小分子神经肽即红色素聚集激素（Redpigmentconcentratinghormone，RPCH）、亮氨酸-脑啡肽（Leucineenkephalin，Leu-ENK）和甲硫氨酸-脑啡肽（Methionineenkephalin，Met-ENK）的结构、特征和生殖调控功能。主要结果如下： （1 ...
曾慧
core
The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction. [PDF]
, 2013 The majority of proteases are synthesized in an inactive form, termed zymogen, which consists of a propeptide and a protease domain. The propeptide is commonly involved in the correct folding and specific inhibition of the enzyme.
Bouaziz, Ahlem +11 more
core +4 more sources
Met-enkephalin-induced mobilization of intracellular Ca2+ in rat intracardiac ganglion neurones [PDF]
, 1999 The effects of Met-enkephalin on Ca2+-dependent K+ channel activity were investigated using the cell-attached patch recording technique on isolated parasympathetic neurones of rat intracardiac ganglia. Large-conductance, Ca2+-dependent K+ channels (BKCa)
Adams +18 more
core +1 more source
Aceite de oliva virgen y regulación hormonal de la presión arterial: una revisión del papel de los enzimas proteolíticos [PDF]
, 2010 Numerosos estudios realizados en los últimos años, han puesto de manifiesto que los niveles elevados de grasa en la dieta están directamente relacionados con el desarrollo de diversas patologías, entre las que destacan enfermedades cardiovasculares ...
Arrazola Saniger, M. +5 more
core