Results 151 to 160 of about 9,189 (204)
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Dopamine and methionine-enkephalin in human brain
Neuroscience Letters, 1982Abstract The contents of dopamine (determined radioenzymatically) and methionine-enkephalin (assayed by a radioimmunoassay) were measured in several areas of the human brain. The peptide was principally localized in dopamine-rich structures. In patients with Parkinson's disease, in contrast to the general dopamine deficiency, the reduction in ...
A, Ploska +8 more
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ENZYME IMMUNOASSAY FOR METHIONINE‐ENKEPHALIN SULFOXIDE
Clinical and Experimental Pharmacology and Physiology, 1990SUMMARY1. An immunoassay technique employing an enzyme‐labelled ligand was developed for the sulfoxide derivative of the opioid peptide methionine‐enkephalin (MOE).2. The sensitivity of the enzyme immunoassay (EIA) was approximately twofold higher than that achieved in the radio‐immunoassay (RIA) using tritiated ligand.
G K, Tiong, J E, Olley
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Alcoholism: Clinical and Experimental Research, 2004
Abstract: Background: Opiate peptides are involved in the physical dependence on ethanol. Levels of methionine enkephalin (MEnk), for example, are affected by ethanol. No study on the effect of ethanol on endomorphin, the endogenous ligand for the μ‐opiate receptor, has yet been conducted.Methods: We examined the effect of ethanol ingestion on serum
William A, Banks +2 more
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Abstract: Background: Opiate peptides are involved in the physical dependence on ethanol. Levels of methionine enkephalin (MEnk), for example, are affected by ethanol. No study on the effect of ethanol on endomorphin, the endogenous ligand for the μ‐opiate receptor, has yet been conducted.Methods: We examined the effect of ethanol ingestion on serum
William A, Banks +2 more
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Totalsynthese von Methionin‐Enkephalin
Angewandte Chemie, 1976Zwanzigfache Normorphin‐Wirkung zeigt das aus Schweinehirn isolierte Pentapeptid (1), das man infolgedessen auch als „endogenes Opiat”︁ bezeichnet hat. Jetzt wird die Totalsynthese dieses Stoffes beschrieben magnified image.
Wolfgang Voelter +4 more
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METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES
International Journal of Peptide and Protein Research, 1980Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino‐ and carboxy‐ terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1 ‐Gly2 peptide bond is replaced ...
DEREK HUDSON +2 more
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Methionine–enkephalin related glycoconjugates
International Journal of Peptide and Protein Research, 1993A series of glycoconjugates, in which [Met5]enkephalin or [d‐Ala2, Met5]enkephalin have been linked through an ester bond to the HO‐6 of various d‐glycopyranose moieties, were synthesized by classical solution methods. The biological activities of these compounds were determined on selective pharmacological preparations: guinea pig ileum and mouse vas ...
Š. HORVAT +5 more
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Effect of methionine-enkephalin on xanthophore aggregation
Peptides, 1980The intracranial injection of an opioid antagonist (naloxone) caused aggregation of xanthophores in goldfish scales. This aggregating effect produced by naloxone was inhibited by an injection of methionine-enkephalin (M-ENK). M-ENK, when injected together with melatonin which normally produces aggregation of xanthophores, interfered with the effect of ...
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The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa +6 more
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Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa +6 more
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Clinical and Experimental Pharmacology and Physiology, 1989
SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
G K, Tiong, J E, Olley
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SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
G K, Tiong, J E, Olley
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Stabilization of methionine-enkephalin in human and rat blood
Life Sciences, 1986Methods of preventing the degradation of 3H-methionine-enkephalin (3H-ME) in human blood both at 37 degrees C and under conditions of immediate cooling were examined. We found that, contrary to previous suggestions, use of aprotinin (with or without immediate cooling) was ineffective in preventing the degradation of 3H-ME in blood.
V J, Aloyo, S A, Mousa, G R, Van Loon
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