Results 81 to 90 of about 109,570 (240)

A top‐down proteomic approach reveals a salivary protein profile able to classify Parkinson's disease with respect to Alzheimer's disease patients and to healthy controls

PROTEOMICS, Volume 24, Issue 3-4, February 2024.
Abstract Parkinson's disease (PD) is a complex neurodegenerative disease with motor and non‐motor symptoms. Diagnosis is complicated by lack of reliable biomarkers. To individuate peptides and/or proteins with diagnostic potential for early diagnosis, severity and discrimination from similar pathologies, the salivary proteome in 36 PD patients was ...
Cristina Contini, Laura Fadda, Greca Lai, Carla Masala, Alessandra Olianas, Massimo Castagnola, Irene Messana, Federica Iavarone, Alessandra Bizzarro, Carlo Masullo, Paolo Solla, Giovanni Defazio, Barbara Manconi, Giacomo Diaz, Tiziana Cabras   +14 more
wiley   +1 more source

Recent developments in capillary and microchip electroseparations of peptides (2021–mid‐2023)

ELECTROPHORESIS, Volume 45, Issue 1-2, Page 165-198, January 2024.
Abstract This review article brings a comprehensive survey of developments and applications of high‐performance capillary and microchip electromigration methods (zone electrophoresis in a free solution or in sieving media, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) for ...
Václav Kašička
wiley   +1 more source

Altered microheterogeneity at several N‐glycosylation sites in OPSCC in constant protein expression conditions

FASEB BioAdvances, Volume 6, Issue 1, Page 26-39, January 2024.
Oropharyngeal squamous cell carcinoma (OPSCC) and control serum samples were processed, isolating then digesting proteins, then enriching into glycopeptides and peptides (1–3). After proteomics, glycopeptides were quantified with MS(4A). Glycopeptide expressions were compared between groups (5), then significantly different glycopeptides targeted using
Amy Dickinson, Sakari Joenväärä, Tiialotta Tohmola, Jutta Renkonen, Petri Mattila, Timo Carpén, Antti Mäkitie, Suvi Silén   +7 more
wiley   +1 more source

Multi-Overlap Simulations for Transitions between Reference Configurations [PDF]

, 2003
We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration. This allows one to overcome free energy barriers in the overlap variable. Subsequently, we generalize the approach to deal with the overlaps with respect to two reference configurations
arxiv   +1 more source

Dengzhanshengmai capsule alleviates heart failure and concomitantly decreases phenylacetylglutamine level, interacting with the intestinal microflora in rats

Microbial Biotechnology, Volume 17, Issue 1, January 2024.
The intestinal flora disorder in rats with heart failure (HF) promoting the synthesis of microbial metabolite phenylacetylglutamine (PAGIn) could aggravate HF. Dengzhanshengmai (DZSM) capsule alleviates HF and concomitantly decreases PAGIn level, interacting with the intestinal microflora in rats.
Bojiao Yi, Pin Zhang, Jiemei Chen, Zhengyu Fang, Xiaofang Yang, Dawei Yang, Qingce Zang, Jing Xu, Tianying Ren, Hongjun Yang, Na Guo   +10 more
wiley   +1 more source

Learning Protein Dynamics with Metastable Switching Systems [PDF]

arXiv, 2016
We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint.
arxiv  

Methionine‐enkephalin secreted by human colorectal cancer cells suppresses T lymphocytes

Cancer Science, 2009
The role of methionine‐enkephalin (MENK) as an immunomodulator in colorectal carcinomas (CRC) was examined. MENK was produced in CT26, IEC6A, Colo320, and HT29 CRC cell lines but not in IEC6 intestinal cells.
H. Ohmori, K. Fujii, T. Sasahira, Yi Luo, M. Isobe, N. Tatsumoto, H. Kuniyasu   +6 more
semanticscholar   +1 more source

Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin [PDF]

, 2005
Post-translationally introduced dehydroamino acids often play an important role in the activity and receptor specificity of biologically active peptides.
de Boef, E, Driessen, AJM, Fekken, S, Kluskens, LD, Kuipers, A, Kuipers, OP, Moll, GN, Rink, R   +7 more
core   +2 more sources

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond

Advances in Polymer Technology, Volume 2024, Issue 1, 2024.
Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting a lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM is hydrophilic, while above it, the polymer becomes hydrophobic, making it ideal for thermosensitive drug delivery systems (DDSs).
Siddhi Throat, Sankha Bhattacharya, Songwei Tan   +2 more
wiley   +1 more source

The Catechol‐O‐Methyltransferase (COMT) Val158Met Polymorphism Is Associated with Oxycodone Requirements, Adverse Effects, and Pain Sensitivity in Cancer Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2024, Issue 1, 2024.
Purpose. Catechol‐O‐methyltransferase (COMT) participates in the regulation of dopaminergic and adrenergic neurotransmission. COMT Val158Met polymorphism influences the efficacy and safety of opioids, but its association with oxycodone treatment in patients with cancer pain is yet to be elucidated.
Silu Xu, Nan Wu, Xin Liu, Jiali Zhu, Zhixian Liu, Samuel Silvestre   +5 more
wiley   +1 more source