Results 61 to 70 of about 9,189 (204)
Oral naltrexone treatment for cholestatic pruritus: A double-blind, placebo-controlled study [PDF]
, 1997 Background and Aims: The efficacy of currently available therapeutic agents for cholestatic pruritus is often disappointing. The aim of this study was to assess the antipruritic effect of naltrexone, an oral opiate receptor antagonist.
Bertolotti, M. (M.) +5 more
core +4 more sources
Addiction Biology, Volume 30, Issue 9, September 2025.Rat basolateral amygdala principal neurons projecting to the nucleus accumbens (BLANAc) and bed nucleus of the stria terminalis (BLABNST) represent independent cell populations. In male BLANAc neurons only (left), CIE/WD decreases feedforward GABA release from lateral paracapsular interneurons.
Michaela E. Price +6 more
wiley +1 more source
How Far Does a Receptor Influence Vibrational Properties of an Odorant? [PDF]
, 2016 The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory
Kongsted, Jacob +3 more
core +3 more sources
Studies on the small neuropeptide: RPCH and ENK, their function of reproductive regulation in the mud crab, Scylla paramamosain (Estampador, 1949) [PDF]
, 2013 拟穴青蟹（Scyllaparamamosain）是我国东南沿海重要的经济蟹类。本文以拟穴青蟹为研究对象，采用动物生理学、分子生物学、生物信息学等方法和手段，研究了3种小分子神经肽即红色素聚集激素（Redpigmentconcentratinghormone，RPCH）、亮氨酸-脑啡肽（Leucineenkephalin，Leu-ENK）和甲硫氨酸-脑啡肽（Methionineenkephalin，Met-ENK）的结构、特征和生殖调控功能。主要结果如下： （1 ...
曾慧
core
Opioid receptors in cardiovascular function
British Journal of Pharmacology, Volume 182, Issue 16, Page 3710-3725, August 2025.Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari +4 more
wiley +1 more source
A novel non-Opioid binding site for endomorphin-1 [PDF]
, 2016 Endomorphins are natural amidated opioid tetrapeptides with the following structure: Tyr-Pro-Trp-Phe-NH2 (endomorphin-1),and Tyr-Pro-Phe-Phe-NH2 (endomorphin-2).
Benyhe, S. +8 more
core
Kinetics of chymotrypsin- and papain-catalysed synthesis of [leucine]enkephalin and [methionine]enkephalin [PDF]
Biochemical Journal, 1984 The proteinase-catalysed synthesis of [Leu]enkephalin and [Met]enkephalin was studied kinetically. N alpha-t-Butoxycarbonyl-amino acids and peptides or their ethyl esters served as acyl donors, and amino acid phenylhydrazides were used as acyl acceptors.
openaire +3 more sources
International Endodontic Journal, Volume 58, Issue 8, Page 1126-1145, August 2025.Abstract Background Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene‐related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic ...
Javier Caviedes‐Bucheli +7 more
wiley +1 more source
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body [PDF]
, 2017 Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade.
Annese, Valentina +3 more
core +2 more sources
Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka +5 more
wiley +1 more source