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Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation

Peptides, 1983
Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
K S, Hui   +5 more
exaly   +3 more sources

Biochemistry of the enkephalins and enkephalin-containing peptides

Archives of Biochemistry and Biophysics, 1983
The enkephalins are present in many tissues not only as the free pentapeptides, but also as internal sequences in larger polypeptides of varying size. Fourteen enkephalin-containing peptides (EC peptides) from beef adrenal medulla were isolated and sequenced, and the presence of a protein that contained several [Met]enkephalin sequences and one of [Leu]
S, Udenfriend, D L, Kilpatrick
openaire   +2 more sources

Biosynthesis of the Enkephalins and Enkephalin-Containing Polypeptides

Annual Review of Pharmacology and Toxicology, 1983
The biochemical characterization of the enkephalins and the enkephalin-containing polypeptides and their biosynthesis has reached an advanced state. From the structural data showing great similarities between human and beef proenkephalin there is strong evidence for physiological roles for some of the extended enkephalins and for at least two of the ...
R V, Lewis, A S, Stern
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Enkephalins as immunomodulators

International Journal of Immunopharmacology, 1983
The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. Significant increases in number of survivors were observed in mice treated with enkephalins.
N P, Plotnikoff, G C, Miller
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Enkephalins and Endorphins

1979
Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
R J, Miller, P, Cuatrecasas
openaire   +2 more sources

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