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Enhanced antinociception of mixed efficacy opioid peptidomimetics through P-glycoprotein modulation. [PDF]

open access: yesJ Pharmacol Exp Ther
Anand JP   +5 more
europepmc   +1 more source

Proenkephalin 119-159 in Heart Failure: From Pathophysiology to Clinical Implications. [PDF]

open access: yesJ Clin Med
Matsiras D   +7 more
europepmc   +1 more source
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Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation

Peptides, 1983
Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
Miriam Banay-Schwartz   +2 more
exaly   +3 more sources

Enkephalin mydriasis in mice

European Journal of Pharmacology, 1980
Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
A D, Korczyn, Y, Eshel, O, Keren
openaire   +2 more sources

Potent tetrapeptide enkephalins

Life Sciences, 1981
Abstract Small peptides with opiate-like activity have generally had structures closely resembling that of the opioid pentapeptide enkephalin: Tyr-Gly-Gly-Phe-Met-COOH. Single deletions of any one of the amino acids has been demonstrated to reduce opiate activity drastically.
R E, Chipkin   +6 more
openaire   +2 more sources

On the Origin of Leu-Enkephalin and Met-Enkephalin in the Rat Neurohypophysis

Endocrinology, 1985
The posterior lobe of the pituitary contains large amounts of Leu- and Met-enkephalin (LE and ME, respectively). A marked depletion of ME (81.9%) and LE (94.5%) in the posterior pituitary occurred after transection of the pituitary stalk. This indicates that most, if not all, of the enkephalins are in processes of central neurons. In the present study,
openaire   +2 more sources

Enkephalin-cell interactions

2000
Enkephalin analogs for multivalent ligand systems, bivalent enkephalins, multivalent enkephalins on polymers, multivalent ligands on vesicles, simultaneous activation of two different receptor systems, and cell interactions of enkephalin/polypeptide conjugates are described.
S, Kimura, Y, Imanishi
openaire   +2 more sources

Enkephalin in the goldfish retina

Cellular and Molecular Neurobiology, 1986
Enkephalin-like immunoreactive amacrine cells were visualized using the highly sensitive avidin-biotin method. The somas of these cells were situated in the inner nuclear and ganglion cell layers. Enkephalin-stained processes were observed in layers 1, 3, and 5 of the inner plexiform layer.
Y Y, Su, K R, Fry, D M, Lam, C B, Watt
openaire   +2 more sources

Cerebral application of enkephalins

Experientia, 1977
Implantation of enkephalins A or B into the ventral thalamus or injection into the lateral ventricle of rats evoked only weak signs of stereotyped behavior, but did not cause gnawing.
F, Bergmann   +7 more
openaire   +2 more sources

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