Results 31 to 40 of about 405 (144)

Novel Antimicrobial Agents for Gram-Negative Pathogens

Antibiotics, 2023
Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a global level during the last decades and represent an everyday challenge, especially for the hospital practice of our era.
Marios Karvouniaris, Maria Panagiota Almyroudi, Mohd Hafiz Abdul-Aziz, Stijn Blot, Elisabeth Paramythiotou, Evdoxia Tsigou, Despoina Koulenti   +6 more
doaj   +1 more source

In vitro activity of cefiderocol, cefepime/enmetazobactam, cefepime/zidebactam, eravacycline, omadacycline, and other comparative agents against carbapenem-non-susceptible Pseudomonas aeruginosa and Acinetobacter baumannii isolates associated from bloodstream infection in Taiwan between 2018–2020

Journal of Microbiology, Immunology and Infection, 2022
Background/purpose: This study aimed to investigate the in vitro susceptibilities of carbapenem-non-susceptible Pseudomonas aeruginosa (CNSPA) and Acinetobacter baumannii (CNSAB) isolates to cefiderocol, novel β-lactamase inhibitor (BLI) combinations ...
Po-Yu Liu, Wen-Chien Ko, Wen-Sen Lee, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Min-Chi Lu, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Pei-Lan Shao, Yu-Lin Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Hung-Jen Tang, Po-Ren Hsueh   +23 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam. [PDF]

FEBS Lett
β‐Lactamase‐catalysed hydrolysis is the primary form of β‐lactam antibiotic resistance in Gram‐negative bacteria. The penicillanic acid sulfone (PAS) enmetazobactam is thought to inhibit extended‐spectrum β‐lactamases (ESBLs) by fragmentation of an initial acyl‐enzyme to form an active‐site lysinoalanine cross link.
Beer M, Hinchliffe P, Hanževački M, Bethel CR, Tooke CL, Van der Kamp MW, Papp-Wallace KM, Bonomo RA, Shapiro S, Mulholland AJ, Spencer J.   +10 more
europepmc   +2 more sources

Fruits Vinegar : Quality Characteristics, Phytochemistry, and Functionality [PDF]

, 2021
The popularity of fruits vinegar (FsV) has been increased recently as a healthy drink wealthy in bioactive compounds that provide several beneficial properties.
Bakour, Meryem, Conte, Raffaele, El Arabi, Ilham, El Ghouizi, Asmae, Hano, Christophe, Laaroussi, Hassan, Lyoussi, Badiaa, Mechchate, Hamza, Ousaaid, Driss   +8 more
core   +2 more sources

Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli [PDF]

, 2021
Methicillin-resistant Staphylococcus aureus (MRSA) and resistant Escherichia coli (rE.coli) infections can spread rapidly. Further they are associated with high morbidity and mortality from treatment failure.
Shah, A., Shah, A., Ward, M., Ward, M., Yagnik, D., Yagnik, D.   +5 more
core   +1 more source

Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model

Antimicrobial Agents and Chemotherapy, 2020
Third-generation cephalosporin (3GC)-resistant Enterobacteriaceae are classified as critical priority pathogens, with extended-spectrum β-lactamases (ESBLs) as principal resistance determinants. Enmetazobactam (formerly AAI101) is a novel ESBL inhibitor developed in combination with cefepime for empirical treatment ...
Fabian Bernhard, Rajesh Odedra, Sylvie Sordello, Rossella Cardin, Samantha Franzoni, Cédric Charrier, Adam Belley, Peter Warn, Matthias Machacek, Philipp Knechtle   +9 more
openaire   +3 more sources

Nuevos inhibidores de β-lactamasas frente a patógenos gram negativos multirresistentes [PDF]

, 2022
Programa Oficial de Doutoramento en Ciencias da Saúde. 5007V01[Resumo] As especies Acinetobacter baumannii, Pseudomonas aeruginosa e a orde Enterobacterales son categorizados como patóxenos de prioridade crítica para o desenvolvemento de novos ...
Vázquez-Ucha, Juan Carlos
core  

Carbapenemase Inhibitors: Updates on Developments in 2021 [PDF]

, 2022
Carbapenem resistance, an emerging global health problem, compromises the treatment of infections caused by nosocomial pathogens. Preclinical and clinical trials demonstrate that a new generation of carbapenemases inhibitors, together with the recently ...
Allam, Sabine, Hajjar, Rayan El, Hassan, Sally Al, Naji, Amal, Shaker, Waleed Mohamed, Zeineddine, Nabil, Zerdan, Maroun Bou, Zerdan, Morgan Bou   +7 more
core   +1 more source

Reply to Shapiro, “Cefepime/Enmetazobactam Is a Clinically Effective Combination Targeting Extended-Spectrum β-Lactamase-Producing Enterobacterales ”

Antimicrobial Agents and Chemotherapy, 2022
International ...
Vázquez-Ucha, Juan, Lasarte-Monterrubio, Cristina, Guijarro-Sánchez, Paula, Oviaño, Marina, Álvarez-Fraga, Laura, Alonso-García, Isaac, Arca-Suárez, Jorge, Bou, German, Beceiro, Alejandro   +8 more
openaire   +4 more sources

Antibiotics needed to treat multidrug-resistant infections in neonates. [PDF]

, 2022
Infections remain a leading cause of death in neonates. The sparse antibiotic development pipeline and challenges in conducting neonatal research have resulted in few effective antibiotics being adequately studied to treat multidrug-resistant (MDR ...
Agarwal, R, Balasegaram, M, Bielicki, JA, Bradley, J, Ellis, S, Giaquinto, C, Nambiar, S, Noel, GJ, O'Brien, S, Qazi, SA, Sharland, M, Velaphi, S, Williams, PC   +12 more
core   +1 more source