Iranian Journal of Microbiology, 2022 Background and Objectives: Escherichia coli (E. coli) is an important member of Enterobacteriaceae family involved in severe infections. The increased rate of resistance towards different classes of antibiotics limits their treatment options. The aim of
Ashraf Ahmed Kadry +2 more
doaj +1 more source
Biochemical exploration of β-lactamase inhibitors [PDF]
, 2023 The alarming rise of microbial resistance to antibiotics has severely limited the efficacy of current treatment options. The prevalence of β-lactamase enzymes is a significant contributor to the emergence of antibiotic resistance.
Debasish Kar, Varshaa Arer
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Novel Antimicrobial Agents for Gram-Negative Pathogens
Antibiotics, 2023 Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a global level during the last decades and represent an everyday challenge, especially for the hospital practice of our era.
Marios Karvouniaris +6 more
doaj +1 more source
P24 In vitro activity of cefepime/enmetazobactam, and comparators, against OXA carbapenemase-positive Acinetobacter baumannii [PDF]
JAC-Antimicrobial ResistanceAbstract Background Cefepime/enmetazobactam (FEP/META) is a new β-lactam/β-lactamase inhibitor combination with broad-spectrum activity against MDR Enterobacterales (including OXA-48-producing isolates) which has demonstrated superiority to piperacillin/tazobactam for the treatment of complicated ...
Jon Ward +4 more
openalex +2 more sources
Recommendations to Synthetize Old and New β-Lactamases Inhibitors: A Review to Encourage Further Production [PDF]
, 2022 open2The increasing emergence of bacteria producing β-lactamases enzymes (BLEs), able to inactivate the available β-lactam antibiotics (BLAs), causing the hydrolytic opening of their β-lactam ring, is one of the global major warnings.
Alfei, Silvana, Zuccari, Guendalina
core +1 more source
Comparison of in vitro activity of cefepime-enmetazobactam and other carbapenem-sparing agents for gram-negative uropathogens [PDF]
IP International Journal of Medical Microbiology and Tropical DiseasesKalaivani Ramakrishnan +4 more
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Antimicrobial resistance conferred by OXA-48 β-lactamases:towards a detailed mechanistic understanding [PDF]
, 2021 OXA-48-type β-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales. These enzymes are of high and growing clinical significance due to the importance of carbapenems in treatment of health care ...
Hirvonen, Viivi H A +2 more
core +2 more sources
P38 Re-assessment of the primary efficacy outcomes of cefepime/enmetazobactam versus piperacillin/tazobactam in adult patients with complicated urinary tract infections or acute pyelonephritis using updated EUCAST piperacillin/tazobactam susceptibility breakpoints [PDF]
JAC Antimicrob ResistJon Ward +4 more
europepmc +2 more sources
Panorama Actual del MedicamentoCefepima/enmetazobactam (CEF/ENM) es una nueva combinación de cefepima, antibiótico betalactámico del grupo de las cefalosporinas de cuarta generación, y enmetazobactam, un inhibidor de betalactamasas estructuralmente relacionado con tazobactam. El medicamento ha sido autorizado con indicación en el tratamiento de las infecciones complicadas del tracto
Pablo Caballero Portero
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Fruits Vinegar : Quality Characteristics, Phytochemistry, and Functionality [PDF]
, 2021 The popularity of fruits vinegar (FsV) has been increased recently as a healthy drink wealthy in bioactive compounds that provide several beneficial properties.
Bakour, Meryem +8 more
core +2 more sources