Results 61 to 70 of about 527 (153)

Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli [PDF]

, 2021
Methicillin-resistant Staphylococcus aureus (MRSA) and resistant Escherichia coli (rE.coli) infections can spread rapidly. Further they are associated with high morbidity and mortality from treatment failure.
Shah, A., Shah, A., Ward, M., Ward, M., Yagnik, D., Yagnik, D.   +5 more
core   +1 more source

Monte-Carlo simulations to assess the probability of target attainment for cefepime and enmetazobactam in patients with complicated urinary tract infections

Monte-Carlo simulations to assess the probability of target attainment for cefepime and enmetazobactam in patients with complicated urinary tract infections
Jannik Vollmer, Juan Quevedo, N. Dunkel, Anne Santerre Henriksen, Matthias Macháček   +4 more
openalex   +2 more sources

Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 2020
Klebsiella pneumoniae strains that produce extended-spectrum beta lactamases (ESBLs) are a persistent public health threat. There are relatively few therapeutic options, and there is undue reliance on carbapenems. Alternative therapeutic options are urgently required.
Adam Johnson, Laura McEntee, Nicola Farrington, Ruwanthi Kolamunnage‐Dona, Samantha Franzoni, A. Vezzelli, Mameli Massimiliano, Philipp Knechtle, Adam Belley, Aaron Dane, George L. Drusano, Shampa Das, William Hope   +12 more
openalex   +5 more sources

Carbapenemase Inhibitors: Updates on Developments in 2021 [PDF]

, 2022
Carbapenem resistance, an emerging global health problem, compromises the treatment of infections caused by nosocomial pathogens. Preclinical and clinical trials demonstrate that a new generation of carbapenemases inhibitors, together with the recently ...
Allam, Sabine, Hajjar, Rayan El, Hassan, Sally Al, Naji, Amal, Shaker, Waleed Mohamed, Zeineddine, Nabil, Zerdan, Maroun Bou, Zerdan, Morgan Bou   +7 more
core   +1 more source

Nuevos inhibidores de β-lactamasas frente a patógenos gram negativos multirresistentes [PDF]

, 2022
Programa Oficial de Doutoramento en Ciencias da Saúde. 5007V01[Resumo] As especies Acinetobacter baumannii, Pseudomonas aeruginosa e a orde Enterobacterales son categorizados como patóxenos de prioridade crítica para o desenvolvemento de novos ...
Vázquez-Ucha, Juan Carlos
core  

An Epidemiological and Pharmacokinetic-pharmacodynamic Investigation into the Impact of Carbapenem-resistant Enterobacterales [PDF]

, 2023
Background: According to the 2019 CDC Antibiotic Resistance Threats Report, more than 2.8 million antibiotic-resistant infections occur in the United States each year, leading to more than 35,000 deaths.
Clark, Justin
core   +2 more sources

Combate à resistência aos antibióticos : novas moléculas/estratégias em fase clínica de desenvolvimento [PDF]

, 2023
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizIntrodução: A resistência antimicrobiana é a capacidade de um microrganismo impedir que um agente antimicrobiano funcione contra ele, impondo sérias limitações no tratamento
Nunes, Pedro Miguel Ascensão
core  

A Review of In Silico and In Vitro Approaches in the Fight Against Carbapenem‐Resistant Enterobacterales

Journal of Clinical Laboratory Analysis, Volume 39, Issue 9, May 2025.
This review highlights computational approaches for discovering antimicrobials against carbapenem‐resistant Enterobacterales. It outlines methods like pharmacophore modeling, molecular docking, and absorption, distribution, metabolism, and excretion–toxicity (ADMET) analysis, integrated with in vitro assays, to identify and validate potential drugs ...
Muhammad Absar, Abdul Rahman Zaidah, Amer Mahmood, Sajjad Ahmad, Hasan Ejaz, Naveed Ahmed, Nik Haszroel Hysham Nik Hashim, Chan Yean Yean   +7 more
wiley   +1 more source

Antibiotics needed to treat multidrug-resistant infections in neonates. [PDF]

, 2022
Infections remain a leading cause of death in neonates. The sparse antibiotic development pipeline and challenges in conducting neonatal research have resulted in few effective antibiotics being adequately studied to treat multidrug-resistant (MDR ...
Agarwal, R, Balasegaram, M, Bielicki, JA, Bradley, J, Ellis, S, Giaquinto, C, Nambiar, S, Noel, GJ, O'Brien, S, Qazi, SA, Sharland, M, Velaphi, S, Williams, PC   +12 more
core   +1 more source

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source