Results 51 to 60 of about 405 (144)

Spontaneous bacterial peritonitis due to carbapenemase-producing Enterobacteriaceae: Etiology and antibiotic treatment [PDF]

, 2020
Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria.
Alfieri A., Di Franco S., Fiore M., Leone S., Martora F., Pace M. C., Passavanti M. B., Petrou S.   +7 more
core   +1 more source

Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia: a systematic review and meta-analysis [PDF]

, 2023
Background Cefiderocol is a last resort option for carbapenem-resistant (CR) Gram-negative bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and CR Acinetobacter baumannii.
Karakonstantis, S., Kritsotakis, E.I., Rousaki, M., Vassilopoulou, L.   +3 more
core   +1 more source

Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion [PDF]

, 2022
Antimicrobial resistance represents a serious threat for global health, causing an unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in 2017, carbapenem-resistant organisms were listed by the WHO among the group of
Atripaldi L., Borrelli A., Calo F., Coppola N., Corcione A., De Cristofaro M. G., Durante-Mangoni E., Filippelli A., Franci G., Galdo M., Gentile I., Guglielmi G., Maraolo A. E., Onorato L., Pagliano P., Perrella A., Piazza O., Picardi M., Punzi R., Scotto R., Trama U.   +20 more
core   +1 more source

In vitro activity of cefepime-enmetazobactam on carbapenem-resistant Gram negatives

Clinical Microbiology and Infection
Cefepime-enmetazobactam is a new β-lactam/βlactamase inhibitor combination with broad-spectrum activity against multidrug-resistant Enterobacterales, including extended-spectrum β-lactamase producers. This study evaluated the in vitro activity of cefepime-enmetazobactam towards a collection of carbapenem-resistant Enterobacterales (CRE), Pseudomonas ...
Rémy A, Bonnin, Katy, Jeannot, Anne, Santerre Henriksen, Juan, Quevedo, Laurent, Dortet   +4 more
openaire   +2 more sources

The potential of ethanol extract of white pomegranate leaves (Punica granatum L) as anti-bacterial [PDF]

, 2020
Treatment of infections using penicillin-derived antibiotics such as methicillin has been found to cause antibiotic-resistant bacteria. This bacteria could produce a beta-lactamase enzyme to form a resistant strain.
Arnawa, I Gede Putu, Kambuno, Norma Tiku, Susilawati, Ni Made   +2 more
core   +1 more source

Boronate-Based Inhibitors of Penicillin-Binding Proteins: An Underestimated Avenue for Antibiotic Discovery? [PDF]

Penicillin-binding proteins (PBPs) are essential enzymes involved in bacterial cell wall biosynthesis and represent the primary targets of β-lactam antibiotics.
Emilia Caselli, Fabio Prati, Luca Svolacchia Brusoni, Nicolo Santi, Valentina Villamil   +4 more
core   +1 more source

Piperacillin-tazobactam vs. carbapenems for treating hospitalized patients with ESBL-producing Enterobacterales bloodstream infections: a systematic review and meta-analysis [PDF]

Objectives: To meta-analyze the clinical efficacy of piperacillin-tazobactam vs. carbapenems for treating hospitalized patients affected by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales bloodstream infections (BSIs).
Cojutti, Pier Giorgio, Gatti, Milo, Pea, Federico   +2 more
core   +1 more source

β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development

Pathogens
Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel ...
Angeliki Katsarou, Panagiotis Stathopoulos, Iva D. Tzvetanova, Christina-Maria Asimotou, Matthew E. Falagas   +4 more
doaj   +1 more source

Cefepime-Induced Encephalopathy in Patients Treated for Urinary Tract Infection [PDF]

Cefepime is a fourth-generation cephalosporin antibiotic administered intravenously used to treat various bacterial infections, including urinary tract infections.
Fisher, Mitchell, Inam, Novera, Nisa, Nuzhat, Stewart, Christopher, Sukpraprut-Braaten, Suporn   +4 more
core   +2 more sources

Activity and resistance mechanisms of the third generation tetracyclines tigecycline, eravacycline and omadacycline against nationwide Spanish collections of carbapenemase-producing Enterobacterales and Acinetobacter baumannii [PDF]

Multicenter study[Abstract] Introduction: The rise in multidrug-resistant bacteria challenges clinical microbiology. Tigecycline, eravacycline, and omadacycline show promise against carbapenem-resistant Enterobacterales and Acinetobacter baumannii ...
Alonso-García, Isaac, Arca-Suárez, Jorge, Beceiro, Alejandro, Blanco-Martín, Tania, Bou, Germán, Fernández-López, María del Carmen, García, Patricia, García-Pose, Andrea, González-Pinto, Lucía, Guijarro-Sánchez, Paula, Lasarte-Monterrubio, Cristina, Maceiras, Romina, Muras, Andrea, Outeda-García, Michelle, Rodríguez-Coello, Arianna, Vázquez-Ucha, Juan Carlos   +15 more
core   +1 more source