Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations [PDF]
For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules.
Dramićanin, Aleksandra +3 more
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What do We Know so Far about Ges Carbapenemases, and What Threat do They Pose?
Postępy MikrobiologiiCarbapenemases, classified as bacterial enzymes, have the ability to hydrolyze carbapenems – important broad-spectrum antibiotics. This work attempts to summarize the information on the diversity of Guiana Extended-Spectrum (GES) subgroup of ...
Rutkowski Kamil +6 more
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Clinical Epidemiology and Global HealthBackground: Piperacillin/tazobactam has limited activity against Enterobacterales, which concurrently express ESBL/ampC/OXA-1 beta-lactamases, which are widely prevalent in India.
Yamuna Devi Bakthavatchalam +11 more
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1945. Antibacterial activity of cefepime/enmetazobactam and comparator agents against U.S. Enterobacterales clinical isolates collected from 2019-2021 [PDF]
Open Forum Infect Dis, 2023 Abstract Background The investigational β-lactam/β-lactamase inhibitor combination of cefepime/enmetazobactam (FPE) met criteria for non-inferiority and superiority compared to piperacillin-tazobactam (PTZ) in a phase 3 clinical trial of adult patients with complicated urinary tract infections/acute ...
Belley, Adam +3 more
europepmc +2 more sources
The bacterial etiology and antimicrobial susceptibility of lower respiratory tract infections in Vietnam [PDF]
Background: Lower respiratory tract infection (LRTI) remains the leading infectious cause of morbidity and mortality globally. Key bacterial pathogens include Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli ...
Anh, Pham Hong +17 more
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AbstractExpression of β-lactamases is the primary form of β-lactam antibiotic resistance in Gram-negative bacteria. Enmetazobactam is a penicillanic acid sulfone (PAS) that inhibits extended spectrum β-lactamases (ESBLs) by forming an acyl-enzyme complex that eventually breaks down to an irreversible lysinoalanine crosslink. In contrast, enmetazobactam
Beer M +10 more
europepmc +2 more sources
Resistance of Gram-Negative Bacteria to Eravacycline: A Systematic Review of Data from In Vitro Studies [PDF]
Introduction: Eravacycline is a new fluorocycline antibiotic with a broad spectrum of antimicrobial activity approved for the treatment of patients with complicated intra-abdominal infections.
Falagas, Matthew E. +4 more
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2529. Population pharmacokinetic models for cefepime and enmetazobactam derived from pooled Phase 1 to Phase 3 clinical studies [PDF]
Open Forum Infect Dis, 2023 Abstract Background The investigational β-lactam/β-lactamase inhibitor combination of cefepime (FEP)/enmetazobactam (ENM) met criteria for non-inferiority and superiority compared to piperacillin/tazobactam in a phase 3 clinical trial of adult patients with complicated urinary tract infections (cUTI ...
Vollmer, Jannik +3 more
europepmc +2 more sources
Cefiderocol (Fetroja) as a Treatment for Hospital-Acquired Pneumonia [PDF]
With increasing resistance to conventional antibiotic treatments, especially among gram-negative bacilli, the search for new antibiotics has become critical on a global scale.
Ahmadzadeh, Shahab +10 more
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Molecular epidemiology of carbapenem-resistant Enterobacterales colonization in an intensive care unit. [PDF]
, 2021 Masters Degree. University of KwaZulu-Natal, Durban.Background: Due to the high association with mortality and morbidity, carbapenem-resistant Enterobacterales (CRE) in general, and carbapenem-resistant Klebsiella pneumoniae, in particular, have been ...
Madni, Osama.
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