Experimental Physiology, EarlyView.Abstract Remote ischaemic preconditioning (RIPC) uses brief limb ischaemia to protect distant organs, but the mechanism of travel of the protective signal remains unclear. This study investigated whether endothelial cells (ECs) contribute to RIPC‐induced neuroprotection and the underlying mechanisms.
Xiaojie Wang +11 more
wiley +1 more source
Etiology-oriented rodent models of erectile dysfunction: a narrative review of categorization, modeling strategies, and translational applications. [PDF]
Transl Androl UrolYin F +8 more
europepmc +1 more source
The acute and chronic effects of local aerobic exercise on cardiovascular physiology
Experimental Physiology, EarlyView.Abstract Exercise training has beneficial effects for primary and secondary prevention of cardiovascular disease (CVD). Effects of exercise training have typically been studied in the form of whole‐body exercise training, partly driven by the assumption that larger effects of exercise training can be achieved by involving more and larger muscle groups.
Myrthe P. F. van de Ven +3 more
wiley +1 more source
Glucose-dependent insulinotropic polypeptide receptor agonism improves heart failure with antifibrosis through Akt-dependent nitric oxide signaling. [PDF]
J Biomed SciLee TW, Lee TI, Higa S, Kao YH, Chen YJ.
europepmc +1 more source
Exercise intolerance and impaired aerobic capacity in heart transplant recipients
Experimental Physiology, EarlyView.Abstract Heart transplant recipients exhibit reduced exercise tolerance and persistently diminished aerobic capacity despite exercise training. Exercise tolerance depends on integrated oxygen transport and utilization, which are impaired in heart transplant recipients.
Fred W. Kolkhorst +2 more
wiley +1 more source
Hypertension impairs erectile function in spontaneously hypertensive rats by suppressing adiponectin in the penile corpus cavernosum. [PDF]
Transl Androl UrolPang S, Jiang J, Jiang R.
europepmc +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Investigation of the putative mechanism by which <i>Ferula sinkiangensis</i> leaves alleviate functional Dyspepsia-like symptoms in rats via modulation of the NO/cGMP/PKG signaling pathway. [PDF]
Front PharmacolXia X +7 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson +1 more
wiley +1 more source
The Leaf Aqueous and Ethanolic Extracts of <i>Tricalysia okelensis</i> Hiern. (Rubiaceae) Reverse L-NAME-Induced Hypertension, Cardiac, and Vascular Remodeling in Rats. [PDF]
Adv Pharmacol Pharm SciNokam F +7 more
europepmc +1 more source