Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
The Janus face of L-arginine supplementation in cardiovascular health and aging exploration of underlying mechanisms. [PDF]
Front AgingYang Z, Ming XF, Potenza DM.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet +6 more
wiley +1 more source
BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence. [PDF]
Int J Mol SciDemirtaş H.
europepmc +1 more source
Food Frontiers, Volume 7, Issue 6, November 2026.ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
Editorial Expression of Concern: Biliverdin reductase-A attenuated GMH induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway. [PDF]
J NeuroinflammationZhang Y +7 more
europepmc +1 more source
cGMP Signaling in Arterioles Revealed by FRET‐Based Real‐Time Measurement in Mice In Vivo
Acta Physiologica, Volume 242, Issue 11, November 2026.ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time in vivo upon NO and acetylcholine (ACh) and effects of PDE inhibition ...
Lukas Thiele +6 more
wiley +1 more source
Nitric oxide as a mechanistic link between metabolic dysfunction and cognitive decline in type 2 diabetes. [PDF]
Biochem Soc TransMarçal AL, Laranjinha J, Lourenço CF.
europepmc +1 more source
Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease
Acta Physiologica, Volume 242, Issue 11, November 2026.ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley +1 more source