Results 121 to 130 of about 1,034,286 (328)

Plastiome: Plastisphere-enriched mobile resistome in aquatic environments

Journal of Hazardous Materials
Aquatic microplastics (MPs) act as reservoirs for microbial communities, fostering the formation of a mobile resistome encompassing diverse antibiotic (ARGs) and biocide/metal resistance genes (BMRGs), and mobile genetic elements (MGEs). This collective genetic repertoire, referred to as the "plastiome," can potentially perpetuate environmental ...
Guruge, Keerthi S., Goswami, Prasun, Kanda, Kazuki, Abeynayaka, Amila, Kumagai, Masahiko, Watanabe, Mafumi, Tamamura-Andoh, Yukino   +6 more
openaire   +3 more sources

Semantically enriched navigation for indoor environments

International Journal of Web and Grid Services, 2006
Location-based mobile services have been in use, and studied, for a long time. With the proliferation of wireless networking technologies, users are mostly interested in advanced services that render the surrounding environment (i.e., the building) highly intelligent and significantly facilitate their activities.
Tsetsos, V., Anagnostopoulos, C., Kikiras, P., Hadjiefthymiades, S.   +3 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reducing cross-sucking of group housed calves by an environmental enriched building design [PDF]

, 2007
Group housing is a natural and economic way of raising calves. One major disadvan-tage of group housing calves is the occurrence of cross-sucking as an abnormal behaviour. The main objective of our study on organic calf housing was the reduction of cross-
Georg, Heiko, Ude, Gracia
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Experience-Dependent Structural Plasticity of Adult-Born Neurons in the Aging Hippocampus

Frontiers in Neuroscience, 2019
Synaptic modification in cortical structures underlies the acquisition of novel information that results in learning and memory formation. In the adult dentate gyrus, circuit remodeling is boosted by the generation of new granule cells (GCs) that ...
Mariela F. Trinchero, Magalí Herrero, M. Cristina Monzón-Salinas, Alejandro F. Schinder   +3 more
doaj   +1 more source

Intergenerational Health Responses to Adverse and Enriched Environments [PDF]

Annual Review of Public Health, 2013
Health consequences of relative or absolute poverty constitute a definitive area of study in social medicine. As demonstrated in the extreme example of the Dutch Hunger Winter from 1944 to 1945, prenatal hunger can lead to adult schizophrenia and depression.
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention

Frontiers in Aging Neuroscience
Hearing loss during early life has been linked to later cognitive decline, but the underlying neural mechanisms remain unclear. To investigate the cognitive impact of early hearing loss in humans, adults aged 18–40 years with severe childhood hearing ...
Xuehua Zhou, Huiqian Yu, Yiru Wang, Kaizheng Chen, Xia Shen   +4 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source