Results 11 to 20 of about 61,162,295 (163)

Urine-Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome. [PDF]

J Neurochem
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Martins M, Nugue G, Aguiar A, Souza LRQ, Abrantes PV, Trajano JR, Stelling M, Junqueira M, Rehen S, Guimarães MZP.   +9 more
europepmc   +2 more sources

A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation. [PDF]

FEBS J
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lima LDP, Sriranganadane D, da Silva DL, Drebes Dörr NC, Mello EBS, Dos Reis CV, Lourenço RF, Santos JFTDS, Salmazo A, Miranda BW, Massirer KB, Couñago RM, Alvarez-Martinez CE.   +12 more
europepmc   +2 more sources

ATF4, ZIK1, and PNMA3 Transcriptomic Signatures Predict Chemoradiotherapy Response in Cervical Cancer. [PDF]

Cancer Med
ABSTRACT Background Cervical cancer (CC) is a main malignancy affecting women globally, with a high mortality rate. Chemoradiotherapy resistance is a significant factor in determining treatment outcomes, and prognostic biomarkers are essential for the appropriate selection of therapeutic strategies.
de Melo Neto AB, Queiroz FR, de Souza Melo CP, Duarte BCD, Ferreira JGG, de Amorim IFG, do Amaral LR, Bertarini PLL, de Figueiredo Franco TMR, de Carvalho AT, Martins-Filho OA, de Jesus Jeremias W, da Conceição Braga L, de Oliveira Salles PG, de Souza Gomes M.   +14 more
europepmc   +2 more sources

Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats. [PDF]

Evid Based Complement Alternat Med, 2023
Solidago microglossa DC. (Asteraceae), “arnica brasileira,” is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine‐treated spontaneously hypertensive rats (SHRs).
Lopes KS, Marques AAM, Moreno KGT, Dos Santos AC, Souza RIC, Lourenço ELB, Oliveira RJ, Gomes RDS, Lívero FADR, Gasparotto Junior A.   +9 more
europepmc   +2 more sources

Analysis of Aspergillus spp. Isolates According to Temporal-Spatial, Sociodemographic, and Clinical Variables-Microsatellite Typing of Clinical and Environmental Samples of Aspergillus fumigatus in a University Hospital in Sao Paulo, Brazil. [PDF]

Mycoses
ABSTRACT Background Typing Aspergillus species is crucial for understanding the sources of infection in hospital environments. Objectives This study analysed clinical and air samples as well as their relationship with the clinical forms of aspergillosis.
Fonseca CA, Araujo R, Coelho VC, Camargo CH, Magri MMC, Motta AL, Côrtes MF, Mamana AC, Batista MV, Moreira DVDS, Croce AP, Giudice MC, Costa AN, Demarzo SE, Dos Santos AG, Guimarães T, de Freitas VLT, Costa SF, Shikanai Yasuda MA.   +18 more
europepmc   +2 more sources

Divergent litter traits of riparian plant species between humid and drier biomes within the tropics

Ecography, Volume 2023, Issue 2, February 2023., 2023
Riparian forests provide abundant plant litter – mostly in the form of dead leaves (hereafter litter) – for both forest soils and adjacent stream ecosystems, supporting terrestrial and aquatic detritus‐based food webs. Although the fate of litter is predominantly dependent on its chemical and physical traits, there is limited availability of data on ...
Guilherme Sena, Alan M. Tonin, Adriano Caliman, Marcos Callisto, Neusa Hamada, Luiz U. Hepp, Vânia L. Kowalczuk, Renato T. Martins, Adriana O. Medeiros, Paula B. Morais, Marcelo Moretti, Yara Moretto, Mauricio M. Petrucio, Laís Salgueiro, Luciana S. Carneiro, Gisele M. dos Santos, Edson S. A. Junior, Lorrane A. M. Feitoza, José F. Gonçalves Jr   +18 more
wiley   +1 more source

Genetic Ancestry Reveals Historical Diversity of Formation Across Three Brazilian Communities of African Descent (Quilombos) in Central Brazil [PDF]

Am J Hum Biol
ABSTRACT Introduction Characterized as relatively isolated communities, many Brazilian quilombos were formed during the period of slavery in Brazil when enslaved persons (most of African descent) ran away or were abandoned by their enslavers. Quilombos in Central Brazil, whose settlement was more recent due to the relative isolation of the region ...
Paiva S, Rivara A, de Castro Nóbrega M, Toledo R, Klautau‐Guimarães M, dos Santos S, Madrigal L, de Oliveira S.   +7 more
europepmc   +2 more sources

Caderno de Propostas Didáticas para Aulas de Genética Para Professores do Ensino Fundamental e Médio [PDF]

, 2022
Este material foi produzido de forma colaborativa como produto final da disciplina BG042- Práticas em Genética para os Ensinos Fundamental e Médio, ofertada ao curso de Licenciatura em Ciências Biológicas da Universidade Federal do Paraná na retomada do ...
Vosch, Daniel Nicolas Guimaraes, Rosa, Guilherme Aparecido, De Carvalho, Victor Leon, Graboski, Tiago Beltrão, Cristal, Aline Miranda, Sukow, Natalie Mary, Rosati, Augusto Cesar, Mendonça, Mayana Emanuela de Oliveira, De Souza, Thaís, Dos Santos, Eric Paraguaia, Ferrari, Matheus Felipe, Dahle, Rafaela y Ayuso, Dos Reis, Caroline Mira de Paula, Tureck, Luciane Viater   +13 more
core  

TABULEIRO DE GENES: UMA FERRAMENTA PEDAGÓGICA PARA O ENSINO DE BIOLOGIA

Revista Prática Docente, 2020
Estudantes da educação básica apresentam dificuldades na assimilação dos conceitos de Genética; desse modo, o objetivo deste trabalho é apresentar o jogo “Tabuleiro de Genes” como ferramenta para o ensino de Genética.
Thays Cristina Ribeiro Alves, Marcones Costa, Camila Campêlo de Sousa   +2 more
doaj   +3 more sources

Long-Term Maintenance of Complex Chromosomal Inversion Polymorphism in <i>Drosophila mediopunctata</i>. [PDF]

Ecol Evol
It has become increasingly clear that natural selection favors haplotypes that draw functionally related genes together, often targeting mechanisms that control recombination rates. In this paper, we show that the long‐term maintenance of linkage disequilibrium between linked non‐overlapping chromosomal inversions in a Drosophila species may arise from
Uno F, Rocha FB, Klaczko LB.
europepmc   +2 more sources