Results 41 to 50 of about 817,024 (288)

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System

Frontiers in Neuroscience, 2020
Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes.
Pavithra Chandramowlishwaran, A. Vijay, Daniel Abraham, Ge Li, S. Mwangi, S. Srinivasan   +5 more
semanticscholar   +1 more source

Visualization of the human enteric nervous system by probe confocal laser endomicroscopy: a first real-time observation of Hirschsprung’s disease and allied disorders

BMC Medical Imaging, 2021
Background Our group previously proved that the human enteric nervous system can be visualized with confocal laser endomicroscopy after topical application of cresyl violet using surgically resected intestine specimens.
Atsushi Harada, Naoki Shimojima, Masakuni Kobayashi, Shunsuke Kamba, Seiichi Hirobe, Kazuki Sumiyama   +5 more
doaj   +1 more source

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The gut microbiota affects several physiological processes, including gut motility. Here we observed that germ-free mice have an immature enteric nervous system (ENS) that is normalized upon colonization with a normal microbiota.
F. De Vadder, Estelle Grasset, Louise Mannerås Holm, G. Karsenty, A. Macpherson, Louise E Olofsson, F. Bäckhed   +6 more
semanticscholar   +1 more source

A murine model to study the gut bacteria parameters during complex antibiotics like cefotaxime and ceftriaxone treatment

Computational and Structural Biotechnology Journal, 2021
Background: The globally increasing resistance due to extended-spectrum beta-lactamase producing Enterobacteriaceae is a major concern. The objective of this work was to develop a murine model to study the gut bacteria parameters during complex ...
Matthieu Grégoire, Florian Berteau, Ronan Bellouard, Quentin Lebastard, Philippe Aubert, Jacques Gonzales, François Javaudin, Anne Bessard, Pascale Bemer, Éric Batard, Didier Lepelletier, Michel Neunlist, Emmanuel Montassier, Éric Dailly   +13 more
doaj   +1 more source

The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

iScience
Summary: The neural network of the enteric nervous system (ENS) underlies gastrointestinal functions. However, the molecular mechanisms involved in enteric neuronal connectivity are poorly characterized. Here, we studied the role of semaphorin 5A (Sema5A)
Morgane E. Le Dréan, Catherine Le Berre-Scoul, Vincent Paillé, Martial Caillaud, Thibauld Oullier, Jacques Gonzales, Philippe Hulin, Michel Neunlist, Sophie Talon, Hélène Boudin   +9 more
doaj   +1 more source

Early life interaction between the microbiota and the Enteric Nervous System.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020
Recent studies on humans and their key experimental model, the mouse, have begun to uncover the importance of gastrointestinal (GI) microbiota and Enteric Nervous System (ENS) interactions during developmental windows spanning from conception to ...
Jaime P. P. Foong, Lin Y. Hung, Sabrina S B Poon, T. Savidge, J. Bornstein   +4 more
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesisResearch in context

EBioMedicine, 2019
Background: Colon cancer stem cells (CSCs), considered responsible for tumor initiation and cancer relapse, are constantly exposed to regulatory cues emanating from neighboring cells present in the tumor microenvironment.
Simon Valès, Gregory Bacola, Mandy Biraud, Mélissa Touvron, Anne Bessard, Fanny Geraldo, Kelsie A. Dougherty, Shaian Lashani, Céline Bossard, Mathurin Flamant, Emilie Duchalais, Séverine Marionneau-Lambot, Thibauld Oullier, Lisa Oliver, Michel Neunlist, François M. Vallette, Laurianne Van Landeghem   +16 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source