ABSTRACT Background Early‐onset neonatal infections are among the most common neonatal diseases. However, the long‐term outcomes of the infections are not well understood. Objective To study the association between early‐onset neonatal infection and attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods A nationwide
Mads Andersen+4 more
wiley +1 more source
Systematic Analysis of Mobile Genetic Elements Mediating β-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections [PDF]
Noncarbapenemase-producing carbapenem-resistant Enterobacterales (non-CP-CRE) are increasingly recognized as important contributors to prevalent carbapenem-resistant Enterobacterales (CRE) infections. However, there is limited understanding of mechanisms
Aitken, S.+16 more
core +1 more source
Intestinal colonization with multidrug-resistant Enterobacterales (MDRE-IC) increases the risk of MDRE bloodstream infection (BSI). However, its impact on the overall risk of nosocomial Enterobacterales bloodstream infections (nE-BSIs) remains unclear. This study aimed to determine this risk and identify associated factors in hospitalized patients.This
Noureddine Henoun Loukili+7 more
openaire +3 more sources
Bacteremia in Pediatric Solid Organ Transplant Recipients within 1 Year of Transplant
We retrospectively reviewed bloodstream infections (BSI) in pediatric recipients of solid organ transplants over a 14‐year period. Overall BSI rates were significant but decreased over time. Risk factors for BSI were identified which may help identify interventions which further decrease rates.
Mario M. Landa+8 more
wiley +1 more source
Effectiveness of empiric carbapenem versus non-carbapenem therapy for extended-spectrum β-lactamase producing Enterobacterales infections in non-intensive care unit patients: a real-world investigation in a hospital with high-prevalence of extended-spectrum β-lactamase producing Enterobacterales [PDF]
ObjectiveTo investigate whether empiric carbapenem therapy, compared to empiric non-carbapenem therapy, was associated with improved clinical outcomes among hospitalized, non-intensive care unit (ICU) patients with extended-spectrum β-lactamase (ESBL ...
Elkomos, Mary+5 more
core +2 more sources
Susceptibility of carbapenemase-producing Enterobacterales (CPE) to nitroxoline
AbstractBackgroundInfections caused by carbapenemase-producing Enterobacterales (CPE) constitute a major global health concern and are associated with increased morbidity and mortality. Nitroxoline is an old antibiotic, which has recently been re-launched for the treatment of uncomplicated urinary tract infection.
Frieder Fuchs, Axel Hamprecht
openaire +3 more sources
Abstract Background To harmonize with the EUCAST breakpoints, the French Society of Microbiology introduced a change in the inhibition diameter breakpoint (17 mm versus 20 mm previously) of temocillin.
Eric Farfour+8 more
openaire +2 more sources
Population pharmacokinetics and optimized dosing of cefuroxime in critically ill patients
Abstract Cefuroxime is a second‐generation cephalosporin widely used in the intensive care unit (ICU). ICU patients have high variability in interpatient pharmacokinetics (PK), but the extent of this variation is unclear. We performed an observational PK study in ICU patients.
Jaap W. A. Mouton+9 more
wiley +1 more source
Piperacillin-tazobactam vs. carbapenems for treating hospitalized patients with ESBL-producing Enterobacterales bloodstream infections: a systematic review and meta-analysis [PDF]
Objectives: To meta-analyze the clinical efficacy of piperacillin-tazobactam vs. carbapenems for treating hospitalized patients affected by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales bloodstream infections (BSIs).
Cojutti, Pier Giorgio+2 more
core +1 more source
Chloramphenicol activity against carbapenemase producing Enterobacterales
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Camarlinghi, Giulio+6 more
openaire +3 more sources