Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
Unraveling the Enterococcus enigma in ICU peritonitis: a multicenter cohort study. [PDF]
Bardoul M +8 more
europepmc +1 more source
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Assessing Recreational Safety of Urban Marine Waters: Long-Term Coliform and Enterococcus Analysis. [PDF]
Ringenary MJ, Tanacredi JT, Frame GW.
europepmc +1 more source
ABSTRACT Aim Bacterial biofilms around the apex are crucial in disease progression and persistence of apical periodontitis. While intracanal biofilms initiate infection, extraradicular biofilms contribute to treatment resistance and persistence. Thus, a comprehensive understanding of these biofilms may help elucidate mechanisms underlying persistent ...
Yoko Asahi +11 more
wiley +1 more source
Probiotic Enterococcus faecium (M74) as an alternative to antibiotics for controlling necrotic enteritis in broiler chickens. [PDF]
Mostafa AEA, Ramadan R, Sittien A.
europepmc +1 more source
Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay +4 more
wiley +1 more source
Isolation and evaluation of antagonistic activity against pathogenic bacteria by Lactobacillus and Enterococcus spp. from the saliva of Speothos venaticus and Chrysocyon brachyurus. [PDF]
Silva MLOM +8 more
europepmc +1 more source
Impact of Electronic Cigarette Use on the Oral Microbiota: A Systematic Review
ABSTRACT Aim To examine whether the oral microbiota of e‐cigarette users differs from that of never smokers and current smokers. Materials and Methods PubMed, Scopus and Web of Science were searched on 27 August 2025. Human studies using molecular methods to compare oral microbiota in saliva, subgingival plaque and oral mucosal swabs among e‐cigarette ...
Giusy Rita Maria La Rosa +9 more
wiley +1 more source
Molecular insights into antimicrobial resistance and virulence in hospital-associated of vancomycin-resistant Enterococcus faecium isolates in a tertiary hospital in Bangkok Thailand. [PDF]
Wongsuk T +6 more
europepmc +1 more source

